Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival-Reference-Cited by-同舟云学术

Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

Published:2023-09-08 Issue:9 Volume:59 Page:1628
ISSN:1648-9144
Container-title:Medicina
language:en
Short-container-title:Medicina

Author:

Santonja Carlos¹,Morillo-Giles Daniel²,Prieto-Pareja Elena²,Soto-de Ozaeta Carlos²,Serrano-del Castillo Cristina²,Salgado-Sánchez Rocío²,Yi-Shi Ana-Wu-Yang¹,Manso Rebeca¹,Rodríguez-Pinilla Socorro María¹

Affiliation:

1. Departments of Pathology, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain

2. Departments of Haematology, Hospital Universitario Fundación Jiménez Díaz, 28040 Madrid, Spain

Abstract

Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.

Funder

Fondos FEDER-ISCIII

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/1648-9144/59/9/1628/pdf

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