Polymorphism Patterns and Socioeconomic Characteristics and Their Influence on the Risk of Preeclampsia

Author:

Socol Flavius George1,Craina Marius234,Abu-Awwad Simona-Alina23ORCID,Socol Ioana Denisa1,Farcas Simona Sorina5,Abu-Awwad Ahmed67ORCID,Serban Denis3,Bucur Adina-Ioana89ORCID,Bernad Elena234ORCID,Boscu Lioara1,Popa Laura Claudia5,Andreescu Nicoleta Ioana5ORCID

Affiliation:

1. Doctoral School, University of Medicine and Pharmacy “Victor Babeş”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania

2. Ist Clinic of Obstetrics and Gynecology, “Pius Brinzeu” County Clinical Emergency Hospital, 300723 Timisoara, Romania

3. Department of Obstetrics and Gynecology, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

4. Center for Laparoscopy, Laparoscopic Surgery and In Vitro Fertilization, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania

5. Department of Microscopic Morphology—Genetics, Center of Genomic Medicine, University of Medicine and Pharmacy “Victor Babes”, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania

6. Department XV—Discipline of Orthopedics—Traumatology, “Victor Babes” University of Medicine and 21 Pharmacy, 300041 Timisoara, Romania

7. Research Center University Professor Doctor Teodor Sora, “Victor Babes” University of Medicine and 23 Pharmacy, 300041 Timisoara, Romania

8. Institute of Cardiovascular Diseases Timisoara, 300310 Timisoara, Romania

9. Department of Functional Sciences, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy from Timișoara, 300041 Timișoara, Romania

Abstract

Background: Preeclampsia (PE) is a critical condition affecting pregnancies worldwide. Understanding its etiology, particularly the genetic factors, is vital. This study aims to investigate the association between ACE gene polymorphisms, specifically the ACE G2350A (rs4343) variant, and the predisposition to PE, offering insights into the genetic predisposition towards this complex condition. Methods: A case-control study was conducted with 140 participants without PE (Control Group) and 128 participants diagnosed with PE (PE Group). The study focused on comparing the prevalence of the rs4343 polymorphism between the groups. Results: The analysis identified a significantly reduced risk associated with the AG genotype and an insignificant increase in risk with the AA genotype. Statistically significant differences in demographic and clinical characteristics, such as BMI and marital status, were observed between the groups, suggesting a multifaceted risk profile for PE that includes genetic, environmental, and socio-economic factors. Conclusions: The study highlight the significant role of genetic variations, specifically the ACE G2350A (rs4343) polymorphism, in influencing PE predisposition. It highlights the intricate interplay between genetic predispositions and other risk factors in the development of PE. Further research is encouraged to expand on these findings and explore a wider range of genetic polymorphisms and their interactions with environmental factors.

Funder

Victor Babes University of Medicine and Pharmacy Timisoara

Publisher

MDPI AG

Reference37 articles.

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5. Fountain, J.H., Kaur, J., and Lappin, S.L. (2023, May 12). Physiology, Renin Angiotensin System, StatPearls [Internet], Available online: https://www.ncbi.nlm.nih.gov/books/NBK470410/.

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