Transcoronary Gradients of Mechanosensitive MicroRNAs as Predictors of Collateral Development in Chronic Total Occlusion
Author:
Vural Mustafa Gökhan1ORCID, Temel Hulya Yilmaz2, Turunc Ezgi3, Akdemir Ramazan4, Tatli Ersan4, Agac Mustafa Tarik4
Affiliation:
1. Department of Cardiology, University of Health Sciences, Ankara Training and Research Hospital, Ankara 06230, Turkey 2. Department of Bioengineering, Faculty of Engineering, Ege University, Bornova 35040, Turkey 3. Department of Biochemistry, Faculty of Pharmacy, Izmir Katip Celebi University, Izmir 35620, Turkey 4. Department of Cardiology, Faculty of Medicine, Sakarya University, Sakarya 54050, Turkey
Abstract
Background and Objectives: In this present study, we investigated the impact of mechanosensitive microRNAs (mechano-miRs) on the collateral development in 126 chronic total occlusion (CTO) patients, selected from 810 undergoing angiography. Materials and Methods: We quantified the collateral blood supply using the collateral flow index (CFI) and assessed the transcoronary mechano-miR gradients. Results: The patients with favorable collaterals had higher CFI values (0.45 ± 0.02) than those with poor collaterals (0.38 ± 0.03, p < 0.001). Significant differences in transcoronary gradients were found for miR-10a, miR-19a, miR-21, miR-23b, miR-26a, miR-92a, miR-126, miR-130a, miR-663, and let7d (p < 0.05). miR-26a and miR-21 showed strong positive correlations with the CFI (r = 0.715 and r = 0.663, respectively), while let7d and miR-663 were negatively correlated (r = −0.684 and r = −0.604, respectively). The correlations between cytokine gradients and mechano-miR gradients were also significant, including Transforming Growth Factor Beta with miR-126 (r = 0.673, p < 0.001) and Vascular Endothelial Growth Factor with miR-10a (r = 0.602, p = 0.002). A regression analysis highlighted the hemoglobin level, smoking, beta-blocker use, miR-26a, and miR-663 as significant CFI determinants, indicating their roles in modulating the collateral vessel development. Conclusions: These findings suggest mechanosensitive microRNAs as predictive biomarkers for collateral circulation, offering new therapeutic perspectives for CTO patients.
Reference45 articles.
1. Coronary Chronic Total Occlusion (CTO): A Review;Koelbl;Rev. Cardiovasc. Med.,2018 2. Revascularization of chronic total occlusion coronary artery and cardiac regeneration;Liao;Front. Cardiovasc. Med.,2022 3. The dynamics of the coronary collateral circulation;Zimarino;Nat. Rev. Cardiol.,2014 4. Monocytic microRNA profile associated with coronary collateral artery function in chronic total occlusion patients;Hakimzadeh;Sci. Rep.,2017 5. Hakimzadeh, N., Nossent, A.Y., van der Laan, A.M., Schirmer, S.H., de Ronde, M.W., Pinto-Sietsma, S.J., van Royen, N., Quax, P.H., Hoefer, I.E., and Piek, J.J. (2015). Circulating MicroRNAs Characterizing Patients with Insufficient Coronary Collateral Artery Function. PLoS ONE, 10.
|
|