Wettability and Stability of Naproxen, Ibuprofen and/or Cyclosporine A/Silica Delivery Systems

Abstract

The characteristics of the wetting process of the porous surface of silica gel when penetrated by base liquids (water and n-octane), ethanol and stable drug systems (naproxen, ibuprofen and cyclosporine A), as biologically active substances in two ethanol concentrations, were determined by the wetting rate vs. time. The tests were performed for contacted and non-contacted plates with the vapours of the wetting liquid. Thin-layer liquid chromatography was used to determine the penetration rate of the SiO2-coated plates, taking into account the linear dependence consistent with the Washburn equation. Additionally, the changes in the adhesive tension ΔG were determined for the tested drugs. Drug stability tests were conducted using the dynamic light scattering technique and microelectrophoresis. The penetration time of the plate depends on the properties and structure of the wetting liquid droplets. The types of interactions (dispersive, electrostatic and hydrogen bonding) formed between the silanol surface groups of the silica gel and the groups contained in the adsorbate particles are also very important factors. The greater the impact force, the slower the wetting process due to the strong penetration of the liquid into the pores of the substrate. The characteristics of the drug wetting/stability process may contribute to the development of their new forms, creating delivery systems with greater efficiency and lower side effects.