Consistency of the Estimator for the Common Mean in Fixed-Effect Meta-Analyses

Author:

Taketomi Nanami1,Emura Takeshi12ORCID

Affiliation:

1. Biostatistics Center, Kurume University, Kurume 830-0011, Japan

2. Research Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tokyo 190-8562, Japan

Abstract

Fixed-effect meta-analyses aim to estimate the common mean parameter by the best linear unbiased estimator. Besides unbiasedness, consistency is one of the most fundamental requirements for the common mean estimator to be valid. However, conditions for the consistency of the common mean estimator have not been discussed in the literature. This article fills this gap by clarifying conditions for making the common mean estimator consistent in fixed-effect meta-analyses. In this article, five theorems are devised, which state regularity conditions for the common mean estimator to be consistent. These theorems are novel applications of the classical large sample theory to meta-analyses. Numerical illustrations are also given to help understand the needs of the regularity conditions. Three real datasets illustrate the practical consequences of the devised theorems. This article concludes that the inconsistency of the common mean estimator occurs under some conditions in real meta-analyses.

Funder

JSPS KAKENHI

Publisher

MDPI AG

Subject

Geometry and Topology,Logic,Mathematical Physics,Algebra and Number Theory,Analysis

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