Stabilization Control for a Class of Fractional-Order HIV-1 Infection Model with Time Delays

Abstract

In this study, we investigated a novel asymptotic stabilization control method for a fractional-order HIV-1 infection model. First, we constructed a mathematical model of the fractional-order HIV-1 infection using the state-space equations of Caputo fractional calculus. Subsequently, a new control strategy was designed for the fractional-order HIV-1 infection model, and the corresponding asymptotic stabilization criterion was proposed by combining a novel vector Lyapunov function with the M-matrix method. Additionally, we incorporated a time delay, which was generated by the interaction between different variables in the actual system, into the fractional-order HIV-1 infection model, forming a system with a time delay. Based on the vector Lyapunov function associated with the M-matrix measure and Razumikhin interpretation, a control strategy was developed for the fractional-order HIV-1 infection model with a time delay. Finally, we show the results of two numerical simulations of the fractional-order HIV-1 infection model, with and without time delay, to illustrate the accuracy, usefulness, and universality of the proposed measure in our paper.