Affiliation:
1. National Institute of Gastroenterology—IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, Italy
Abstract
Background: Steatosis is the most common liver disease worldwide and the leading cause of liver-associated morbidity and mortality. The aim of this study was to explore the differences in blood parameters and dietary habits in non-obese patients with and without steatosis. Methods: The present study included 987 participants with BMI < 30, assessed in the fourth recall of the MICOL study. Patients were divided by steatosis grade, and a validated food frequency questionnaire (FFQ) with 28 food groups was administered. Results: The prevalence of non-obese participants with steatosis was 42.86%. Overall, the results indicated many statistically significant blood parameters and dietary habits. Analysis of dietary habits revealed that non-obese people with or without steatosis had similar dietary habits, although higher daily amounts of red meat, processed meat, ready meals, and alcohol were recorded in participants with liver disease (p < 0.05). Conclusions: Many differences were found in non-obese people with and without steatosis, but in light of a network analysis, the two groups demonstrated similar dietary habits, proving that pathophysiological, genetic, and hormonal patterns are probably the basis of their liver status, regardless of weight. Future genetic analyses will be performed to analyze the expression of genes involved in the development of steatosis in our cohort.
Funder
Italian Ministry of Health with Ricerca Corrente 2023
Subject
Food Science,Nutrition and Dietetics
Reference70 articles.
1. Global burden of NALFD and NASH: Trends, predictions, risk factors and prevention;Younozzi;Nat. Rev. Gastroenterol. Hepatol.,2018
2. Nonalcoholic fatty liver disease in lean subject: Is it all metabolic-associated fatty liver diasease?;Machado;Hepatoma Res.,2020
3. Nonalcoholic fatty liver disease in lean individuals in the United States;Younossi;Medicine,2012
4. Lean non-alcoholic fatty liver disease (lean-NAFLD) and the development of metabolic syndrome: A retrospective study;Wang;Sci. Rep.,2022
5. Risk for development of severe liver disease in lean patients with nonalcoholic fatty liver disease: A long-term follo-up study;Nasr;Hepatol. Commun.,2017
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