Alcohol-Associated Liver Disease Outcomes: Critical Mechanisms of Liver Injury Progression

Author:

Osna Natalia A.12ORCID,Tikhanovich Irina3,Ortega-Ribera Martí4ORCID,Mueller Sebastian56ORCID,Zheng Chaowen5,Mueller Johannes5,Li Siyuan5,Sakane Sadatsugu78ORCID,Weber Raquel Carvalho Gontijo78,Kim Hyun Young78,Lee Wonseok78,Ganguly Souradipta78,Kimura Yusuke78,Liu Xiao78,Dhar Debanjan7ORCID,Diggle Karin78,Brenner David A.79,Kisseleva Tatiana8,Attal Neha10,McKillop Iain H.10ORCID,Chokshi Shilpa1112,Mahato Ram13ORCID,Rasineni Karuna14,Szabo Gyongyi4,Kharbanda Kusum K.21415ORCID

Affiliation:

1. Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68106, USA

2. Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68106, USA

3. Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA

4. Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA

5. Center for Alcohol Research, University of Heidelberg, 69120 Heidelberg, Germany

6. Viscera AG Bauchmedizin, 83011 Bern, Switzerland

7. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA

8. Department of Surgery, University of California San Diego, La Jolla, CA 92093, USA

9. Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA

10. Department of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC 28203, USA

11. The Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE59NT, UK

12. School of Microbial Sciences, King’s College, London SE59NT, UK

13. Department of Pharmaceutical Science, College of Pharmacy, University of Nebraska Medical Center, Omaha, NE 68106, USA

14. Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68106, USA

15. Research Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, USA

Abstract

Alcohol-associated liver disease (ALD) is a substantial cause of morbidity and mortality worldwide and represents a spectrum of liver injury beginning with hepatic steatosis (fatty liver) progressing to inflammation and culminating in cirrhosis. Multiple factors contribute to ALD progression and disease severity. Here, we overview several crucial mechanisms related to ALD end-stage outcome development, such as epigenetic changes, cell death, hemolysis, hepatic stellate cells activation, and hepatic fatty acid binding protein 4. Additionally, in this review, we also present two clinically relevant models using human precision-cut liver slices and hepatic organoids to examine ALD pathogenesis and progression.

Funder

National Institute of Health

The Foundation for Liver Research

US Department of Veterans Affairs, Biomedical Laboratory Research, and Development Service

Publisher

MDPI AG

Reference218 articles.

1. Prevalence of alcohol-associated liver disease: A systematic review and meta-analysis;Amonker;Hepatol. Commun.,2023

2. Alcoholic liver disease epidemiology in the united states: A retrospective analysis of 3 us databases;Dang;Am. J. Gastroenterol.,2020

3. Fibrosis and alcohol-related liver disease;Lackner;J. Hepatol.,2019

4. Alcohol and the mechanisms of liver disease;Chen;J. Gastroenterol. Hepatol.,2023

5. Epigenetics—New frontier for alcohol research;Shukla;Alcohol Res.,2013

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