Autopsy by Imaging: The Last 10 Years

Abstract

Virtual autopsies (VAs) are non-invasive, bypassing many of the challenges posed by traditional autopsies (TAs). This is a literature review about the sensitivity of the main VA techniques: post mortem (PM) computed tomography (PMCT) and PM magnetic resonance (PMMR). This could help to identify the most appropriate uses for VA, and where future research should focus. A review was performed, searching for literature from the last 10 years regarding how sensitive VA is at detecting common lesions that could cause or contribute to death. 33 studies were included. There was strong agreement that PMCT had strengths in detecting: free gas; fractures; large fluid accumulations; and calcifications. PMCT’s weaknesses included missing: pulmonary emboli; myocardial infarctions; and visceral/soft tissue lesions. The strengths of PMMR were less widely agreed, but included detecting: large fluid collections; myocardial infarctions; and visceral/soft tissue lesions. There were no wide agreements on PMMR’s weaknesses due to a lack of literature. Therefore, VA is a useful adjunct to TA; however, its drawbacks in reliably detecting common causes of death restrict its ability to fully replace TA. Novel imaging techniques are being developed in order to bridge the current gaps of VA, and make autopsies even less invasive.