UPLC-MS/MS Analysis of Naturally Derived Apis mellifera Products and Their Promising Effects against Cadmium-Induced Adverse Effects in Female Rats
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Published:2022-12-27
Issue:1
Volume:15
Page:119
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ISSN:2072-6643
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Container-title:Nutrients
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language:en
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Short-container-title:Nutrients
Author:
Amr Alaa, Abd El-Wahed AidaORCID, El-Seedi Hesham R., Khalifa Shaden A. M., Augustyniak MariaORCID, El-Samad Lamia M.ORCID, Abdel Karim Ahmed E., El Wakil AbeerORCID
Abstract
Honeybee products arouse interest in society due to their natural origin and range of important biological properties. Propolis (P) and royal jelly (RJ) attract scientists’ attention because they exhibit antioxidant, anti-inflammatory, anti-bacterial, anti-tumor, and immunomodulatory abilities. In this study, we tested whether P and RJ could mitigate the adverse effects of cadmium (Cd) exposure, with particular emphasis on the reproductive function in female rats. In this line, one week of pretreatment was established. Six experimental groups were created, including (i) the control group (without any supplementation), (ii) the Cd group (receiving CdCl2 in a dose of 4.5 mg/kg/day), (iii) the P group (50 mg of P/kg/day), (iv) RJ group (200 mg of RJ/kg/day), (v) P + Cd group (rats pretreated with P and then treated with P and Cd simultaneously), (vi) RJ + Cd group (animals pretreated with RJ before receiving CdCl2 simultaneously with RJ). Cd treatment of rats adversely affected a number of measured parameters, including body weight, ovarian structure and ultrastructure, oxidative stress parameters, increased ovarian Cd content and prolonged the estrous cycle. Pretreatment and then cotreatment with P or RJ and Cd alleviated the adverse effects of Cd, transferring the clusters in the PCA analysis chart toward the control group. However, clusters for cotreated groups were still distinctly separated from the control and P, or RJ alone treated groups. Most likely, investigated honeybee products can alter Cd absorption in the gut and/or increase its excretion through the kidneys and/or mitigate oxidative stress by various components. Undoubtedly, pretreatment with P or RJ can effectively prepare the organism to overcome harmful insults. Although the chemical composition of RJ and P is relatively well known, focusing on proportion, duration, and scheme of treatment, as well as the effects of particular components, may provide interesting data in the future. In the era of returning to natural products, both P and RJ seem valuable materials for further consideration as anti-infertility agents.
Subject
Food Science,Nutrition and Dietetics
Reference66 articles.
1. Yosri, N., El-Wahed, A.A.A., Ghonaim, R., Khattab, O.M., Sabry, A., Ibrahim, M.A.A., Moustafa, M.F., Guo, Z., Zou, X., and Algethami, A.F.M. (2021). Anti-viral and immunomodulatory properties of propolis: Chemical diversity, pharmacological properties, preclinical and clinical applications, and in silico potential against SARS-CoV-2. Foods, 10. 2. Salama, S., Shou, Q., Abd El-Wahed, A.A., Elias, N., Xiao, J., Swillam, A., Umair, M., Guo, Z., Daglia, M., and Wang, K. (2022). Royal jelly: Beneficial properties and synergistic effects with chemotherapeutic drugs with particular emphasis in anticancer strategies. Nutrients, 14. 3. Noh, S., Go, A., Kim, D.B., Park, M., Jeon, H.W., and Kim, B. (2020). Role of antioxidant natural products in management of infertility: A review of their medicinal potential. Antioxidants, 9. 4. Honey, propolis, and royal jelly: A comprehensive review of their biological actions and health benefits;Pasupuleti;Oxid. Med. Cell. Longev.,2017 5. Proteomic analysis of the royal jelly and characterization of the functions of its derivation glands in the honeybee;Fujita;J. Proteome Res.,2013
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