The Role of DAMPS in Burns and Hemorrhagic Shock Immune Response: Pathophysiology and Clinical Issues. Review

Author:

Pantalone Desirè,Bergamini Carlo,Martellucci Jacopo,Alemanno Giovanni,Bruscino Alessandro,Maltinti Gherardo,Sheiterle Maximilian,Viligiardi Riccardo,Panconesi Roberto,Guagni Tommaso,Prosperi Paolo

Abstract

Severe or major burns induce a pathophysiological, immune, and inflammatory response that can persist for a long time and affect morbidity and mortality. Severe burns are followed by a “hypermetabolic response”, an inflammatory process that can be extensive and become uncontrolled, leading to a generalized catabolic state and delayed healing. Catabolism causes the upregulation of inflammatory cells and innate immune markers in various organs, which may lead to multiorgan failure and death. Burns activate immune cells and cytokine production regulated by damage-associated molecular patterns (DAMPs). Trauma has similar injury-related immune responses, whereby DAMPs are massively released in musculoskeletal injuries and elicit widespread systemic inflammation. Hemorrhagic shock is the main cause of death in trauma. It is hypovolemic, and the consequence of volume loss and the speed of blood loss manifest immediately after injury. In burns, the shock becomes evident within the first 24 h and is hypovolemic-distributive due to the severely compromised regulation of tissue perfusion and oxygen delivery caused by capillary leakage, whereby fluids shift from the intravascular to the interstitial space. In this review, we compare the pathophysiological responses to burns and trauma including their associated clinical patterns.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference83 articles.

1. Epidemiology of Burns Injuries Globally https://www.uptodate.com/contents/epidemiology-of-burn-injuries-globally

2. Severe burn injury in europe: a systematic review of the incidence, etiology, morbidity, and mortality

3. Damage-Associated Molecular Patterns and the Systemic Immune Consequences of Severe Thermal Injury

4. American Committee for trauma-American College of Surgeons, Advaced Trauma Life Support, 10th ed https://www.facs.org/quality-programs/trauma

5. Morbidity and Survival Probability in Burn Patients in Modern Burn Care*

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