Antibacterial Activity Assessment of Chitosan/Alginate Lavender Essential Oil Membranes for Biomedical Applications

Author:

Cruz Sánchez Encarnación1ORCID,García María Teresa1ORCID,Gracia Ignacio1ORCID,Fernández-Bermejo Soledad Illescas23,Rodríguez Juan Francisco1ORCID,García-Vargas Jesús Manuel1ORCID,Vidal Roig Dolors2ORCID

Affiliation:

1. Department of Chemical Engineering, Facultad de Ciencias y Tecnologías Químicas, University of Castilla-La Mancha, Avda. Camilo José Cela 12, 13071 Ciudad Real, Spain

2. Department of Medical Sciences, Microbiology Area, Facultad de Medicina, University of Castilla-La Mancha, Paseo de Moledores s/n, 13071 Ciudad Real, Spain

3. Department of Microbiology, Hospital General Universitario de Ciudad Real, Obispo Rafael Torija s/n, 13005 Ciudad Real, Spain

Abstract

The demand for natural products in the treatment of dermatological pathologies has boosted the use of bioactive substances such as lavender essential oil (LEO), which stands out for its anti-inflammatory and antioxidant properties and its antimicrobial potential. Biopolymers such as chitosan (CHT) and alginate (ALG) are biodegradable and biocompatible and have proven their viability in biomedical applications such as skin regeneration. The inhibitory effect of LEO on the growth of skin-related bacterial species Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa and the fungus Candida albicans was studied by incorporating 1% v/v LEO encapsulated in CHT, ALG, and CHT/ALG membranes. Despite the verification of the antimicrobial effect of all type of membranes, no synergistic effect was observed following the addition of LEO. S. aureus and P. aeruginosa showed the most growth on the different substrates and C. albicans demonstrated the highest inhibition. This is a first approach using microorganisms isolated from clinical samples or skin microbiota. Further investigation would be advisable using more clinical strains for each microorganism to validate their biomedical applicability.

Funder

Consejería de Educación, Cultura y Deportes of Junta de Comunidades de Castilla-La Mancha

Publisher

MDPI AG

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