Affiliation:
1. Laboratory of Organic Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-Nishi, Gifu 501-1196, Japan
Abstract
Hydrogen gas (H2) has attracted attention as a next-generation clean energy source. Its efficient and safe preparation and utilization are crucial in both the industry and organic chemistry research. In this study, a Pt/CB (platinum on carbon bead)-catalyzed MW-mediated continuous-flow hydrogenation reaction was developed using methylcyclohexane (MCH) as the reducing agent (hydrogen carrier). Alkynes, alkenes, nitro groups, benzyl esters, and aromatic chlorides were chemoselectively hydrogenated using Pt/CB under MW-assisted continuous-flow conditions. This methodology represents a safe and energy-efficient hydrogenation process, as it eliminates the need for an external hydrogen gas supply or heating jackets as a heating medium. The further application of MW-mediated continuous-flow hydrogenation reactions is a viable option for the efficient generation and utilization of sustainable energy.
Funder
Japan Society for the Promotion of Science (JSPS) KAKENHI
New Energy and Industrial Technology Development Organization
Japan Science Society
Next Generation (SPRING) Program