Effects of Lactobacillus plantarum and Weissella viridescens on the Gut Microbiota and Serum Metabolites of Mice with Antibiotic-Associated Diarrhea

Author:

Yan Zhiwei12,Liu Zhuangzhuang12,Ma Yong12,Yang Zhao12,Liu Gang12ORCID,Fang Jun12

Affiliation:

1. College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China

2. Hunan Provincial Engineering Research Center of Applied Microbial Resources Development for Livestock and Poultry, College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, China

Abstract

Antibiotic-associated diarrhea (AAD) refers to diarrhea caused by gut microbiota disorders after the use of antibiotics, which seriously threatens the health of humans and animals. Therefore, it is necessary to find an effective therapy to treat AAD. This research aimed to explore the effects of Lactobacillus plantarum H-6 (L. plantarum H-6) and Weissella viridescens J-1 (W. viridescens J-1) on alleviating antibiotic-associated diarrhea induced by lincomycin hydrochloride (LH) in mice. The results show that L. plantarum H-6 could significantly reduce the expression of pro-inflammatory factors such as IL-1β and IL-6 in colon tissue. At the same time, L. plantarum H-6 significantly increased the abundance of Lactobacillus and Akkermansia, decreased the abundance of Bacteroides, and increased the contents of L-tryptophan, LysoPC (20:4 (8Z, 11Z, 14Z, 17Z)), reduced riboflavin, threoninyl–methionine, and N-palmitoyl in serum. However, W. viridescens J-1 had little effect on the treatment of AAD. It can be concluded that L. plantarum H-6 can regulate mice’s colonic microbial composition, improve their serum metabolic process, and alleviate antibiotic-associated diarrhea. This research may provide a novel therapeutic option for AAD.

Funder

Hunan Provincial Science and Technology Department

Double first-class construction project of Hunan Agricultural University

Postgraduate Scientific Research Innovation Project of Hunan Province

Science and Technology Innovation and Entrepreneurship Project for University Students of Hunan Province

National Key Research and Development Program

Publisher

MDPI AG

Subject

Food Science,Nutrition and Dietetics

Reference65 articles.

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