Affiliation:
1. Department of Gastroenterology, Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China
Abstract
The purpose of this study was to investigate the effect of body mass index (BMI) on the prevalence of overt hepatic encephalopathy (OHE) after the transjugular intrahepatic portosystemic shunt (TIPS) procedure in decompensated cirrhotic patients. A retrospective observational cohort study of 145 cirrhotic patients receiving TIPS was carried out in our department from 2017 to 2020. The relationships between BMI and clinical outcomes including OHE, as well as risk factors of developing post-TIPS OHE, were analyzed. BMI was categorized as normal weight (18.5 ≤ BMI < 23.0 kg/m2), underweight (BMI < 18.5 kg/m2), and overweight/obese (BMI ≥ 23.0 kg/m2). Among the 145 patients, 52 (35.9%) were overweight/obese and 50 (34%) had post-TIPS OHE. Overweight/obese patients more frequently had OHE compared with normal weight patients (OR: 2.754, 95% CI: 1.236–6.140; p = 0.013). Overweight/obesity (p = 0.013) and older age (p = 0.030) were independent risk factors for post-TIPS OHE according to the logistic regression analysis. Kaplan–Meier curve analysis suggested that overweight/obese patients had the highest cumulative incidence of OHE (log-rank p = 0.0118). In conclusion, overweight/obesity and older age may raise the risk of post-TIPS OHE in cirrhotic patients.
Funder
Nanjing Health Science, Technology Development Special Fund project-Key project
Outstanding Youth Fund project
Drum Tower Hospital, Medical School of Nanjing University
Reference47 articles.
1. World Health Organization (2000). Obesity: Preventing and Managing the Global Epidemic. Report of a WHO Consultation, World Health Organization.
2. Physical inactivity, excess adiposity and premature mortality;Katzmarzyk;Obes. Rev. Off. J. Int. Assoc. Study Obes.,2003
3. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis;Hourigan;Hepatology,1999
4. Liver fibrosis in overweight patients;Ratziu;Gastroenterology,2000
5. Prospective Study of Outcomes in Adults with Nonalcoholic Fatty Liver Disease;Sanyal;N. Engl. J. Med.,2021
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献