Titanium Dioxide-Based Nanoparticles to Enhance Radiation Therapy for Cancer: A Literature Review-Reference-Cited by-同舟云学术

Titanium Dioxide-Based Nanoparticles to Enhance Radiation Therapy for Cancer: A Literature Review

Published:2024-05-31 Issue:2 Volume:5 Page:60-74
ISSN:2624-845X
Container-title:Journal of Nanotheranostics
language:en
Short-container-title:JNT

Author:

Nakayama Masao¹²³^ORCID,Akasaka Hiroaki²⁴,Sasaki Ryohei²^ORCID,Geso Moshi¹^ORCID

Affiliation:

1. Discipline of Medical Radiations, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC 3083, Australia

2. Division of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuou-ku, Kobe 650-0017, Japan

3. Division of Radiation Therapy, Kita-Harima Medical Center, 926-250 Ichibacho, Ono 675-1392, Japan

4. Department of Chemical Engineering, The University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia

Abstract

Titanium dioxide nanoparticles (TiO2 NPs) have been investigated as one of the potential dose enhancement agents for radiation therapy. The role of TiO2 NPs as a photodynamic sensitiser has been well documented, but its sensitisation with X-rays is not highlighted. Unlike other metal NPs, such as gold NPs, the main challenge for TiO2 NPs as radiosensitisers is their low atomic number, resulting in a small cross-section for X-rays. This review summarises the results of current research in this area to explore the dose enhancement inflicted by TiO2 NPs, which could potentially be of great value in improving radiation therapy efficiency.

Publisher

MDPI AG

Link

https://www.mdpi.com/2624-845X/5/2/4/pdf

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