The Glioblastoma CircularRNAome-Reference-Cited by-同舟云学术

The Glioblastoma CircularRNAome

Published:2023-09-26 Issue:19 Volume:24 Page:14545
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Tirpe Alexandru¹²^ORCID,Streianu Cristian²,Tirpe Stefana Maria³,Kocijancic Anja⁴,Pirlog Radu¹^ORCID,Pirlog Bianca⁵,Busuioc Constantin⁶⁷,Pop Ovidiu-Laurean⁸,Berindan-Neagoe Ioana¹^ORCID

Affiliation:

1. Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania

2. The Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania

3. Department of Neurology, Ortenau-Klinikum Lahr, Klostenstrasse 19, 7933 Lahr, Germany

4. Department of Microbiology, Oslo University Hospital, N-0424 Oslo, Norway

5. Department of Neurology, County Emergency Hospital, 400012 Cluj-Napoca, Romania

6. Department of Pathology, National Institute of Infectious Disease, 021105 Bucharest, Romania

7. Department of Pathology, Onco Team Diagnostic, 010719 Bucharest, Romania

8. Department of Morphological Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania

Abstract

Glioblastoma remains one of the most aggressive cancers of the brain, warranting new methods for early diagnosis and more efficient treatment options. Circular RNAs (circRNAs) are rather new entities with increased stability compared to their linear counterparts that interact with proteins and act as microRNA sponges, among other functions. Herein, we provide a critical overview of the recently described glioblastoma-related circRNAs in the literature, focusing on their roles on glioblastoma cancer cell proliferation, survival, migration, invasion and metastasis, metabolic reprogramming, and therapeutic resistance. The main roles of circRNAs in regulating cancer processes are due to their regulatory roles in essential oncogenic pathways, including MAPK, PI3K/AKT/mTOR, and Wnt, which are influenced by various circRNAs. The present work pictures the wide implication of circRNAs in glioblastoma, thus highlighting their potential as future biomarkers and therapeutic targets/agents.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/19/14545/pdf

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