Microporous Polymer-Modified Glassy Carbon Electrodes for the Electrochemical Detection of Metronidazole: Experimental and Theoretical Insights

Author:

Quiroz-Arturo Héctor1,Reinoso Carlos2,Scherf Ullrich3ORCID,Palma-Cando Alex1ORCID

Affiliation:

1. Grupo de Investigación Aplicada en Materiales y Procesos (GIAMP), School of Chemical Sciences and Engineering, Yachay Tech University, Hda. San José s/n y Proyecto Yachay, Urcuqui 100115, Ecuador

2. School of Physical Sciences and Nanotechnology, Yachay Tech University, Hda. San José s/n y Proyecto Yachay, Urcuqui 100115, Ecuador

3. Department of Chemistry, Macromolecular Chemistry and Wuppertal Center for Smart Materials @ Systems (CM@S), Bergische Universität Wuppertal, Gaußstr. 20, 42119 Wuppertal, Germany

Abstract

The persistence and potential toxicity of emergent pollutants pose significant threats to biodiversity and human health, emphasizing the need for sensors capable of detecting these pollutants at extremely low concentrations before treatment. This study focuses on the development of glassy carbon electrodes (GCEs) modified by films of poly-tris(4-(4-(carbazol-9-yl)phenyl)silanol (PTPTCzSiOH), poly-4,4′-Di(carbazol-9-yl)-1,1′-biphenyl (PCBP), and poly-1,3,5-tri(carbazol-9-yl)benzene (PTCB) for the detection of metronidazole (MNZ) in aqueous media. The films were characterized using electrochemical, microscopy, and spectroscopy techniques, including scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Monomers were electropolymerized through cyclic voltammetry and chronoamperometry techniques. Computational methods at the B3LYP/def2-TZVP level were employed to investigate the structural and electrochemical properties of the monomers. The electrochemical detection of MNZ utilized the linear sweep voltammetry technique. Surface characterization through SEM and XPS confirmed the proper electrodeposition of polymer films. Notably, MPN-GCEs exhibited higher detection signals compared to bare GCEs up to 3.6 times in the case of PTPTCzSiOH-GCEs. This theoretical study provides insights into the structural, chemical, and electronic properties of the polymers. The findings suggest that polymer-modified GCEs hold promise as candidates for the development of electrochemical sensors.

Publisher

MDPI AG

Subject

General Materials Science,General Chemical Engineering

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