Affiliation:
1. Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin 300072, China
Abstract
Viral vectors play a pivotal role in the field of gene therapy, with several related drugs having already gained clinical approval from the EMA and FDA. However, numerous viral gene therapy vectors are currently undergoing pre-clinical research or participating in clinical trials. Despite advancements, the innate response remains a significant barrier impeding the clinical development of viral gene therapy. The innate immune response to viral gene therapy vectors and transgenes is still an important reason hindering its clinical development. Extensive studies have demonstrated that different DNA and RNA sensors can detect adenoviruses, adeno-associated viruses, and lentiviruses, thereby activating various innate immune pathways such as Toll-like receptor (TLR), cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS-STING), and retinoic acid-inducible gene I–mitochondrial antiviral signaling protein (RLR-MAVS). This review focuses on elucidating the mechanisms underlying the innate immune response induced by three widely utilized viral vectors: adenovirus, adeno-associated virus, and lentivirus, as well as the strategies employed to circumvent innate immunity.
Funder
Ministry of Science and Technology of the People’s Republic of China, National Key Research and Development Program of China
National Natural Science Foundation of China, the Youth Fund of the National Natural Science Foundation of China
Subject
Virology,Infectious Diseases
Reference150 articles.
1. Sato-Dahlman, M., LaRocca, C.J., Yanagiba, C., and Yamamoto, M. (2020). Adenovirus and Immunotherapy: Advancing Cancer Treatment by Combination. Cancers, 12.
2. Adeno-associated virus vector as a platform for gene therapy delivery;Wang;Nat. Rev. Drug Discov.,2019
3. Immune Responses to Viral Gene Therapy Vectors;Shirley;Mol. Ther.,2020
4. Type I interferon inhibits antibody responses induced by a chimpanzee adenovirus vector;Hensley;Mol. Ther.,2007
5. Evading the immune response upon in vivo gene therapy with viral vectors;Sack;Curr. Opin. Mol. Ther.,2009
Cited by
7 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献