Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular–Kidney

Role of Ectopic Olfactory Receptors in the Regulation of the Cardiovascular–Kidney–Metabolic Axis

Published:2024-04-25 Issue:5 Volume:14 Page:548
ISSN:2075-1729
Container-title:Life
language:en
Short-container-title:Life

Author:

Beito Mitchell R.¹,Ashraf Sadia¹,Odogwu Dorcas¹,Harmancey Romain¹^ORCID

Affiliation:

1. Division of Cardiology, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA

Abstract

Olfactory receptors (ORs) represent one of the largest yet least investigated families of G protein-coupled receptors in mammals. While initially believed to be functionally restricted to the detection and integration of odors at the olfactory epithelium, accumulating evidence points to a critical role for ectopically expressed ORs in the regulation of cellular homeostasis in extranasal tissues. This review aims to summarize the current state of knowledge on the expression and physiological functions of ectopic ORs in the cardiovascular system, kidneys, and primary metabolic organs and emphasizes how altered ectopic OR signaling in those tissues may impact cardiovascular–kidney–metabolic health.

Funder

National Institutes of Health

Publisher

MDPI AG

Link

https://www.mdpi.com/2075-1729/14/5/548/pdf

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