Antibacterial Behavior of Chitosan-Sodium Hyaluronate-PEGDE Crosslinked Films

Author:

Chuc-Gamboa Martha GabrielaORCID,Cámara Perera Carolina María,Aguilar Ayala Fernando JavierORCID,Vargas-Coronado Rossana Faride,Cauich-Rodríguez Juan ValerioORCID,Escobar-García Diana María,Sánchez-Vargas Luis OctavioORCID,Pacheco NeithORCID,San Román del Barrio Julio

Abstract

Chitosan is a natural polymer that can sustain not only osteoblast adhesion and proliferation for bone regeneration purposes, but it is also claimed to exhibit antibacterial properties towards several Gram-positive and Gram-negative bacteria. In this study, chitosan was modified with sodium hyaluronate, crosslinked with polyethylene glycol diglycidyl ether (PEGDE) and both osteoblast cytotoxicity and antibacterial behavior studied. The presence of sodium hyaluronate and PEGDE on chitosan was detected by FTIR, XRD, and XPS. Chitosan (CHT) films with sodium hyaluronate crosslinked with PEGDE showed a better thermal stability than pristine hyaluronate. In addition, osteoblast cytocompatibility improved in films containing sodium hyaluronate. However, none of the films exhibit antimicrobial activity against Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus while exhibiting low to mild activity against Salmonella typhimurion.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

MDPI AG

Subject

Fluid Flow and Transfer Processes,Computer Science Applications,Process Chemistry and Technology,General Engineering,Instrumentation,General Materials Science

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