Prevalence of Comorbidity between Dry Eye and Allergic Conjunctivitis: A Systematic Review and Meta-Analysis

Author:

Akasaki YasutsuguORCID,Inomata TakenoriORCID,Sung JaemyoungORCID,Nakamura Masahiro,Kitazawa KojiORCID,Shih Kendrick CoORCID,Adachi TakeyaORCID,Okumura YuichiORCID,Fujio Kenta,Nagino Ken,Midorikawa-Inomata Akie,Kuwahara Mizu,Hirosawa Kunihiko,Huang Tianxiang,Morooka Yuki,Shokirova Hurramhon,Eguchi Atsuko,Murakami AkiraORCID

Abstract

This systematic review aimed to determine the comorbid dry eye (DE) and allergic conjunctivitis (AC) prevalence. We searched PubMed and EMBASE for articles published until 22 March 2022, combining the terms “(dry eye OR keratoconjunctivitis sicca) AND allergic conjunctivitis.” Study-specific estimates (DE and AC incidence rates among patients with AC and DE, respectively) were combined using the one-group meta-analysis in a random-effects model. The initial search yielded 700 studies. Five articles reporting AC incidence among individuals with DE and six articles reporting DE incidence among individuals with AC were included in the qualitative synthesis. In these nine articles, the total sample size was 7254 patients. The DE incidence among individuals with AC was 0.9–97.5%; the AC incidence among individuals with DE was 6.2–38.0%. One-group meta-analysis using a random-effects model showed that 47.2% (95% confidence interval: 0.165–0.779; 320/1932 cases) of patients with AC had comorbid DE and 17.8% (95% confidence interval: 0.120–0.236; 793/4855 cases) of patients with DE had comorbid AC, as defined by each article. Complimentary screening and treatment for patients with DE and AC may improve long-term outcomes and prevent chronic ocular damage in highly susceptible populations.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

The Institute for Environmental & Gender-specific Medicine, Juntendo University

Kondou Kinen Medical Foundation

Publisher

MDPI AG

Subject

General Medicine

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