Affiliation:
1. Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, Universidad de Barcelona, 08007 Barcelona, Spain
2. Technical Department, Eugenomic, 08029 Barcelona, Spain
Abstract
Polypharmacy is a global healthcare concern, especially among the elderly, leading to drug interactions and adverse reactions, which are significant causes of death in developed nations. However, the integration of pharmacogenetics can help mitigate these risks. In this study, the data from 483 patients, primarily elderly and polymedicated, were analyzed using Eugenomic®’s personalized prescription software, g-Nomic®. The most prescribed drug classes included antihypertensives, platelet aggregation inhibitors, cholesterol-lowering drugs, and gastroprotective medications. Drug–lifestyle interactions primarily involved inhibitions but also included inductions. Interactions were analyzed considering gender. Significant genetic variants identified in the study encompassed ABCB1, SLCO1B1, CYP2C19, CYP2C9, CYP2D6, CYP3A4, ABCG2, NAT2, SLC22A1, and G6PD. To prevent adverse reactions and enhance medication effectiveness, it is strongly recommended to consider pharmacogenetics testing. This approach shows great promise in optimizing medication regimens and ultimately improving patient outcomes.
Reference26 articles.
1. World Health Organization (WHO) (2019). Medication Safety in Polypharmacy.
2. What Is Polypharmacy? A Systematic Review of Definitions;Masnoon;BMC Geriatr.,2017
3. Failure to Reach a Consensus in Polypharmacy Definition: An Obstacle to Measuring Risks and Impacts—Results of a Literature Review;Taghy;Ther. Clin. Risk Manag.,2020
4. Polypharmacy among Adults Aged 65 Years and Older in the United States: 1988-2010;Charlesworth;J. Gerontol. Ser. A Biol. Sci. Med. Sci.,2015
5. G-Nomic: A New Pharmacogenetics Interpretation Software;Sabater;Pharmgenomics. Pers. Med.,2019