Use of Three-Dimensional Cell Culture Models in Drug Assays for Anti-Cancer Agents in Oral Cancer: Protocol for a Scoping Review

Author:

Freitas de Morais Everton1ORCID,Siquara da Rocha Leonardo de Oliveira23ORCID,de Souza Santos John Lenon23,Freitas Raíza Dias4ORCID,Souza Bruno Solano de Freitas25,Coletta Ricardo D.16ORCID,Gurgel Rocha Clarissa A.23567

Affiliation:

1. Department of Oral Diagnosis, School of Dentistry, University of Campinas (UNICAMP), Piracicaba 13414-903, SP, Brazil

2. Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA), Salvador 40296-710, BA, Brazil

3. Department of Pathology and Forensic Medicine, School of Medicine, Federal University of Bahia, Salvador 40110-100, BA, Brazil

4. Department of Social and Pediatric Dentistry, School of Dentistry, Federal University of Bahia, Salvador 40110-150, BA, Brazil

5. D’Or Institute for Research and Education (IDOR), Salvador 41253-190, BA, Brazil

6. Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba 13414-903, SP, Brazil

7. Department of Propaedeutics, School of Dentistry, Federal University of Bahia, Salvador 40110-150, BA, Brazil

Abstract

Advances in the development of pharmacological treatment in oral cancer require tumor models capable of simulating the complex biology of the tumor microenvironment. The spread of three-dimensional models has changed the scenery of in vitro cell culture techniques, contributing to translational oncology. Still, the full extent of their application in preclinical drug trials is yet to be understood. Therefore, the present scoping review protocol was established to screen the literature on using three-dimensional cell culture models in drug-testing assays in the context of oral cancer. This scoping review will be conducted based on the guidelines established by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review guidelines (PRISMA-ScR). We will search the PubMed/Medline, Web of Science, Scopus, and Embase databases, as well as the gray literature, including peer-reviewed research articles involving 3D models applied to drug-assessment assays in oral cancer published from 1 March 2013 until 1 March 2023. Data will be charted, and findings will be described according to the predetermined questions of interest. We will present these findings in a narrative manner.

Funder

Brazilian Government’s Ministry of Health PRONON initiative

National Council for Scientific and Technological Development

Fundação de Amparo à Pesquisa do Estado de São Paulo-FAPESP

Publisher

MDPI AG

Subject

Medicine (miscellaneous)

Reference51 articles.

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2. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries;Sung;CA Cancer J. Clin.,2021

3. Oral and general health-related quality of life in oral squamous cell carcinoma patients-comparative analysis of different treatment regims;Gondivkar;J. Oral Biol. Craniofac. Res.,2021

4. Molecular Classification of Oral Squamous Cell Carcinoma;Bavle;J. Clin. Diagn. Res.,2016

5. Survival Rates According to Tumour Location in Patients with Surgically Treated Oral and Oropharyngeal Squamous Cell Carcinoma;Jehn;Anticancer Res.,2019

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