New 2-(2,4-Dihydroxyphenyl)benzimidazolines-Reference-Cited by-同舟云学术

New 2-(2,4-Dihydroxyphenyl)benzimidazolines

Published:2023-03-10 Issue:1 Volume:2023 Page:M1602
ISSN:1422-8599
Container-title:Molbank
language:en
Short-container-title:Molbank

Author:

Stremski Yordan¹^ORCID,Bachvarova Maria¹^ORCID,Kirkova Desislava²^ORCID,Statkova-Abeghe Stela¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv “Paisii Hilendarski”, Tzar Asen Str. 24, 4000 Plovdiv, Bulgaria

2. Chemistry of Tobacco and Tobacco Smoke, Tobacco and Tobacco Products Institute, Agricultural Academy, Markovo, 4108 Plovdiv, Bulgaria

Abstract

New 2-(2,4-dihydroxyphenyl)benzimidazolines are synthesized in an easily accessible approach. The method is based on the reaction of resorcinol with in situ-formed electrophilic N-ethoxycarbonylbenzimidazolium reagents. The structure of the two newly formed products was spectrally characterized by 1D and 2D NMR, IR, and MS spectral analyses.

Funder

National Science Fund of the Bulgarian Ministry of Education and Science

Bulgarian Ministry of Education and Science

Publisher

MDPI AG

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://www.mdpi.com/1422-8599/2023/1/M1602/pdf

Reference31 articles.

1. Synthesis and biological evaluation of 2-(phenyl)-3H-benzo[d]imidazole-5-carboxylic acids and its methyl esters as potent anti-breast cancer agents;Karthikeyan;Arab. J. Chem.,2017

2. Benzimidazole-derived compounds designed for different targets of Alzheimer’s disease;Gulcan;Curr. Med. Chem.,2019

3. Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine;Lee;Acta Pharm. Sin. B,2022

4. Design, synthesis and biological evaluation of novel hydroxy-phenyl-1H-benzimidazoles as radical scavengers and UV-protective agents;Bino;J. Enzyme Inhib. Med. Chem.,2017

5. Matysiak, J., Skrzypek, A., Karpinska, M., Czarnecka, K., Szymanski, P., Bajda, M., and Niewiadomy, A. (2019). Biological evaluation, molecular docking, and SAR studies of novel 2-(2,4-dihydroxyphenyl)-1H-benzimidazole analogues. Biomolecules, 9.