SPIONs Magnetophoresis and Separation via Permanent Magnets: Biomedical and Environmental Applications
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Published:2023-11-28
Issue:12
Volume:11
Page:3316
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ISSN:2227-9717
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Container-title:Processes
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language:en
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Short-container-title:Processes
Author:
Wu Xian1, Ciannella Stefano2ORCID, Choe Hyeon1, Strayer Jacob1ORCID, Wu Kai3ORCID, Chalmers Jeffrey1ORCID, Gomez-Pastora Jenifer2ORCID
Affiliation:
1. William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, 151 West Woodruff Avenue, Columbus, OH 43210, USA 2. Department of Chemical Engineering, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA 3. Department of Electrical and Computer Engineering, Texas Tech University, 2500 Broadway, Lubbock, TX 79409, USA
Abstract
Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as cutting-edge materials, garnering increasing attention in recent years within the fields of chemical and biomedical engineering. This increasing interest is primarily attributed to the distinctive chemical and physical properties of SPIONs. Progress in nanotechnology and particle synthesis methodologies has facilitated the fabrication of SPIONs with precise control over parameters such as composition, size, shape, stability, and magnetic response. Notably, these functionalized materials exhibit a remarkable surface-area-to-volume ratio, biocompatibility, and, most importantly, they can be effectively manipulated using external magnetic fields. Due to these exceptional properties, SPIONs have found widespread utility in the medical field for targeted drug delivery and cell separation, as well as in the chemical engineering field, particularly in wastewater treatment. Magnetic separation techniques driven by magnetophoresis have proven to be highly efficient, encompassing both high-gradient magnetic separation (HGMS) and low-gradient magnetic separation (LGMS). This review aims to provide an in-depth exploration of magnetic field gradient separation techniques, alongside a comprehensive discussion of the applications of SPIONs in the context of drug delivery, cell separation, and environmental remediation.
Funder
Texas Tech University through HEF New Faculty Startup, NRUF Startup and Core Research Support Fund the National Heart, Lung, and Blood Institute DARPA
Subject
Process Chemistry and Technology,Chemical Engineering (miscellaneous),Bioengineering
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