Assessment of Epicardial Fat in Children: Its Role as a Cardiovascular Risk Factor and How It Is Influenced by Lifestyle Habits

Author:

Calcaterra Valeria12ORCID,Cena Hellas34ORCID,Garella Vittoria5ORCID,Loperfido Federica3ORCID,Chillemi Claudia5,Manuelli Matteo4,Mannarino Savina5,Zuccotti Gianvincenzo26ORCID

Affiliation:

1. Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy

2. Pediatric Department, Buzzi Children’s Hospital, 20154 Milan, Italy

3. Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy

4. Clinical Nutrition and Dietetics Service, Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri IRCCS, 27100 Pavia, Italy

5. Pediatric Cardiology Unit, “V. Buzzi” Children’s Hospital, 20154 Milan, Italy

6. Department of Biomedical and Clinical Science “L. Sacco”, University of Milan, 20157 Milan, Italy

Abstract

Epicardial adipose tissue (EAT) stands out as a distinctive repository of visceral fat, positioned in close anatomical and functional proximity to the heart. EAT has emerged as a distinctive reservoir of visceral fat, intricately interlinked with cardiovascular health, particularly within the domain of cardiovascular diseases (CVDs). The aim of our overview is to highlight the role of EAT as a marker for cardiovascular risk in children. We also explore the influence of unhealthy lifestyle habits as predisposing factors for the deposition of EAT. The literature data accentuate the consequential impact of lifestyle choices on EAT dynamics, with sedentary behavior and unwholesome dietary practices being contributory to a heightened cardiovascular risk. Lifestyle interventions with a multidisciplinary approach are therefore pivotal, involving a nutritionally balanced diet rich in polyunsaturated and monounsaturated fatty acids, regular engagement in aerobic exercise, and psychosocial support to effectively mitigate cardiovascular risks in children. Specific interventions, such as high-intensity intermittent training and circuit training, reveal favorable outcomes in diminishing the EAT volume and enhancing cardiometabolic health. Future clinical studies focusing on EAT in children are crucial for advancing our understanding and developing targeted strategies for cardiovascular risk management in this population.

Funder

Italian Ministry of University and Research

ON Foods-Research and innovation network on food and nutrition Sustainability, Safety and Security-Working ON Foods

European Union

Publisher

MDPI AG

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