Author:
Reheman Aikebaier,Lu Di,Wang Yifan,Chen Xi,Cao Gang,Wan Chuanxing
Abstract
Tuberculosis (TB), caused by M. tuberculosis (M.tb), is the leading infectious cause of mortality worldwide. The emergence of drug-resistant M.tb has made the control of TB more difficult. In our study, we investigated the ability of microorganism fermentation products from the soil to inhibit M.tb. We successfully identified four fermentation products (Micromonospora chokoriensis, Micromonospora purpureochromogenes, Micromonospora profundi, Streptomyces flavofungini) that inhibited the growth of M.tb in vitro and in intracellular bacteria at 25 μg/mL MIC. Importantly, the fermentation products decreased some essential gene expression levels for M.tb growth. Our data provide the possibility that microbial fermentation products have potential development value for anti-M.tb drugs.
Funder
National Natural Science Foundation of China
Microbial Resources Utilization Innovation Team in Key Field of Xin Jiang Production and Con-struction Corps
Subject
General Veterinary,Animal Science and Zoology