Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica-Reference-Cited by-同舟云学术

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Published:2024-04-12 Issue:4 Volume:22 Page:171
ISSN:1660-3397
Container-title:Marine Drugs
language:en
Short-container-title:Marine Drugs

Author:

Oyadomari Yasumoto¹,Goto Yasuyuki²^ORCID,Suganuma Keisuke³,Kawazu Shin-ichiro³,Becking Leontine E.⁴⁵^ORCID,Fusetani Nobuhiro⁶,Nakao Yoichi¹⁶^ORCID

Affiliation:

1. Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan

2. Graduate School of Agricultural and Life Science, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan

3. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro 080-8555, Japan

4. Aquaculture & Fisheries Group, Wageningen University & Research, P.O. Box 338, Bode 32, 6700 AH Wageningen, The Netherlands

5. Naturalis Biodiversity Center, Darwinweg 2, 23333 CR Leiden, The Netherlands

6. Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan

Abstract

A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

Funder

Waseda University

Japan Society for the Promotion of Science

National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine

Publisher

MDPI AG

Link

https://www.mdpi.com/1660-3397/22/4/171/pdf

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