The Emerging Role of NaF-PET/CT in Detecting Vascular Microcalcification in the Pathogenesis of Neurological Dysfunction

Author:

Teichner Eric M.1ORCID,Subtirelu Robert C.2,Ashok Arjun B.1ORCID,Su Yvonne2,Anderson Victoria A.1ORCID,Writer Milo2,Al-Daoud Omar2ORCID,Ismoilov Miraziz2,Raynor William Y.3ORCID,Werner Thomas J.2,Høilund-Carlsen Poul F.45ORCID,Alavi Abass2ORCID,Revheim Mona-Elisabeth67ORCID

Affiliation:

1. Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA

2. Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA

3. Department of Radiology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA

4. Department of Nuclear Medicine, Odense University Hospital, DK-5000 Odense, Denmark

5. Research Unit of Clinical Physiology and Nuclear Medicine, Department of Clinical Research, University of Southern Denmark, DK-5000 Odense, Denmark

6. The Intervention Centre, Division of Technology and Innovation, Oslo University Hospital, NO-0316 Oslo, Norway

7. Institute of Clinical Medicine, University of Oslo, NO-0316 Oslo, Norway

Abstract

Cerebrovascular disease (CVD) is a global health concern, and early detection is crucial for effective intervention. This case report presents a 31-year-old male patient with multiple cardiac risk factors who underwent positron emission tomography/computed tomography (PET/CT) with 18F-sodium fluoride (NaF) and 18F-fluorodeoxyglucose (FDG) to evaluate for the presence and degree of atherosclerosis in the aorta, carotid arteries, coronary arteries, iliac arteries, and the femoral arteries. Elevated NaF uptake within the bilateral carotid arteries signified substantial ongoing vascular microcalcification. Reduced global brain metabolism and region-specific hypometabolism measured with FDG PET indicated potential cerebrovascular mechanisms that may be influencing neurological function. The findings highlight the potential of emerging PET tracers, such as NaF, to improve the diagnostic accuracy and therapeutic management of CVD. This case emphasizes the importance of a comprehensive diagnostic approach as well as continued investigation into CVD pathophysiology using PET-based techniques, which may guide the development of innovative therapeutic strategies.

Publisher

MDPI AG

Reference22 articles.

1. Writing Group Members, Mozaffarian, D., Benjamin, E.J., Go, A.S., Arnett, D.K., and Blaha, M.J. (2016). Heart disease and stroke statistics: 2016 update—A report from the American Heart Association. Circulation, 133, e38–360.

2. Emerging PET Tracers in Cardiac Molecular Imaging;Singh;Cardiol. Ther.,2023

3. The Use of (18)F-FDG-PET/CT for Diagnosis and Treatment Monitoring of Inflammatory and Infectious Diseases;Glaudemans;Clin. Dev. Immunol.,2013

4. Distribution of Inflammation within Carotid Atherosclerotic Plaques with High-Risk Morphological Features: A Comparison between Positron Emission Tomography Activity, Plaque Morphology, and Histopathology;Figueroa;Circ. Cardiovasc. Imaging,2012

5. Extraction of Coronary Atherosclerotic Plaques From Computed Tomography Imaging: A Review of Recent Methods;Liu;Front. Cardiovasc. Med.,2021

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3