Follistatin Is Associated with Bone Mineral Density in Lean Adolescent Girls with Increased Physical Activity

Author:

Jürimäe Jaak1ORCID,Remmel Liina1,Tamm Anna-Liisa2,Purge Priit1ORCID,Maasalu Katre3,Tillmann Vallo3ORCID

Affiliation:

1. Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, 51008 Tartu, Estonia

2. Department of Physiotherapy and Environmental Health, Tartu Health Care College, 50411 Tartu, Estonia

3. Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, 50406 Tartu, Estonia

Abstract

Follistatin is a member of the activin–follistatin–inhibin hormonal system and is proposed to affect bone metabolism. However, data regarding the effect of follistatin on bone are relatively scarce and contradictory in humans. The purpose of the current study was to investigate possible associations of serum follistatin concentration with bone mineral characteristics in lean and physically active adolescent girls. Bone mineral density, body composition, resting energy expenditure and different energy homeostasis hormones in serum including follistatin, leptin and insulin were investigated. Significant relationships (p < 0.05) between serum follistatin (1275.1 ± 263.1 pg/mL) and whole-body (WB) bone mineral content (r = 0.33), WB areal bone mineral density (aBMD) (r = 0.23) and lumbar spine (LS) aBMD (r = 0.29) values were observed. Serum follistatin remained associated with LS aBMD independent of body fat and lean masses (r = 0.21; p < 0.05). However, the follistatin concentration explained only 3% (R2 × 100; p = 0.049) of the total variance in LS aBMD values. In conclusion, serum follistatin concentrations were associated with bone mineral values in lean adolescent girls with increased physical activity. Follistatin was an independent predictor of lumbar spine areal bone mineral density, which predominantly consists of trabecular bone.

Funder

Estonian Research Council

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

Reference42 articles.

1. Bone mineral accrual from 8 to 30 years of age: An estimation of peak bone mass;Faulkner;J. Bone Miner. Res.,2011

2. Effects of gymnastics activities on bone accrual during growth: A systematic review;J. Sports Sci. Med.,2018

3. The impact of training load on bone mineral density in adolescent swimmers: A structural equation modeling approach;Agostinete;Ped. Exerc. Sci.,2017

4. Determinants of bone outcomes in adolescent athletes at baseline: The PRO-BONE Study;Vlachopoulos;Med. Sci. Sports Exerc.,2017

5. Specific bone mass acquisation in elite female athletes;Maimoun;J. Clin. Endocrinol. Metab.,2013

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3