Mediation Analysis of Waist Circumference in the Association of Gut Microbiota with Insulin Resistance in Children

Author:

Ayala-García Juan Carlos1ORCID,Díaz-Benítez Cinthya Estefhany1ORCID,Lagunas-Martínez Alfredo1ORCID,Orbe-Orihuela Yaneth Citlalli1ORCID,Castañeda-Márquez Ana Cristina2ORCID,Ortiz-Panozo Eduardo3ORCID,Bermúdez-Morales Víctor Hugo1ORCID,Cruz Miguel4ORCID,Burguete-García Ana Isabel1ORCID

Affiliation:

1. Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico

2. Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango 34000, Mexico

3. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca 62100, Mexico

4. Unidad de Investigación Médica en Bioquímica, Centro Médico Nacional Siglo XXI, Ciudad de México 06720, Mexico

Abstract

Background: Persistent gut microbiota (GM) imbalance has been associated with metabolic disease development. This study evaluated the mediating role of waist circumference in the association between GM and insulin resistance (IR) in children. Methods: This cross-sectional study included 533 children aged between 6 and 12. The anthropometry, metabolic markers, and relative abundance (RA) of five intestinal bacterial species were measured. Path coefficients were estimated using path analysis to assess direct, indirect (mediated by waist circumference), and total effects on the association between GM and IR. Results: The results indicated a positive association mediated by waist circumference between the medium and high RA of S. aureus with homeostatic model assessments for insulin resistance (HOMA-IR) and for insulin resistance adiponectin-corrected (HOMA-AD). We found a negative association mediated by waist circumference between the low and medium RA of A. muciniphila and HOMA-IR and HOMA-AD. Finally, when we evaluated the joint effect of S. aureus, L. casei, and A. muciniphila, we found a waist circumference-mediated negative association with HOMA-IR and HOMA-AD. Conclusions: Waist circumference is a crucial mediator in the association between S. aureus and A. muciniphila RA and changes in HOMA-IR and HOMA-AD scores in children.

Funder

Consejo Nacional de Ciencia y Tecnología

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

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