Trends and Pattern of Antibiotic Use in Children in Northern Spain, Interpreting Data about Antibiotic Consumption in Pediatric Outpatients
Author:
Calle-Miguel LauraORCID,
Pérez-Méndez Carlos,
García-García ElisaORCID,
Moreno-Pavón Belén,
Solís-Sánchez GonzaloORCID
Abstract
Monitoring of antibiotic prescription and consumption behavior is crucial. The Access, Watch, and Reserve (AWaRe) classification of antibiotics has been recently introduced in order to measure and improve patterns of antibiotic use. In this study, retrospective data about systemic antibiotic consumption (expressed in defined daily dose per 1000 inhabitants per day (DID)) in pediatric outpatients in a region in northern Spain (around 100,000 children up to 14 years old) from 2005 to 2018 were analyzed and compared with antibiotic consumption in general population in Spain. The pattern of use was analyzed by the percentage of the current AWaRe categories, the Access-to-Watch index, and the amoxicillin index. Data were calculated annually and compared into two periods. Mean antibiotic consumption in pediatric outpatients was 14.0 DID (CI 95% 13.38–14.62). It remained stable throughout the study and was lower than consumption in general population in Spain, particularly from 2016. Changes in the consumption of the main active principles have led to an improvement in the three metrics of the pattern of use. It is important to have a thorough knowledge of the methodology applied in studies about antibiotic consumption. There is a lack of an optimal standardized metric for the pediatric population.
Funder
Fundación Ernesto Sánchez Villares de Pediatría
Subject
Pediatrics, Perinatology and Child Health
Reference24 articles.
1. Antimicrobial Use Metrics and Benchmarking to Improve Stewardship Outcomes
2. Global Antimicrobial Resistance Surveillance System (GLASS) Report: Early Implementation 2020,2020
3. Antimicrobial Consumption Database (ESAC-Net)
https://www.ecdc.europa.eu/en/antimicrobial-consumption/surveillance-and-disease-data/database
4. ATC/DDD: WHO Collaborating Centre for Drug Statistics Methodology
https://www.whocc.no/atc_ddd_methodology/purpose_of_the_atc_ddd_system
5. World Health Organization Model list of Essential Medicines, 21st List,2019
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献