Use of Integrative, Complementary, and Alternative Medicine in Children with Epilepsy: A Global Scoping Review

Author:

Zhu Zahra1ORCID,Dluzynski Daniela1,Hammad Nouran2,Pugalenthi Deepika1,Walser Sarah A.3ORCID,Mittal Rea1,Samanta Debopam4ORCID,Brown Melanie L.5ORCID,Asadi-Pooya Ali A.67ORCID,Kakooza-Mwesige Angelina8,Spalice Alberto9,Capponi Martina9,Lekoubou Alain11011,Kumar Ashutosh112ORCID,Paudel Sita112,Carney Paul R.13,Mainali Gayatra112,Naik Sunil112ORCID

Affiliation:

1. College of Medicine, Penn State University, Hershey, PA 17033, USA

2. School of Medicine, Jordan University of Science and Technology, Al-Ramtha 3030, Jordan

3. Department of Psychiatry, Johns Hopkins Hospital, Baltimore, MD 21287, USA

4. Section of Child Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA

5. Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA

6. Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz 71437, Iran

7. Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA

8. Department of Pediatrics & Child Health, Makerere University College of Health Sciences, Kampala 7062, Uganda

9. Department of Maternal Sciences, University la Sapienza, 00185 Roma, Italy

10. Department of Neurology, Hershey Medical Center, Penn State University, Hershey, PA 17033, USA

11. Department of Public Health Sciences, College of Medicine, Penn State University, Hershey, PA 17033, USA

12. Department of Pediatrics and Neurology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA

13. Pediatric Neurology Division, University of Missouri Health Care, Columbia, MO 65212, USA

Abstract

(1) Background: Epilepsy is one of the most common chronic neurological disorders in childhood. Complementary and alternative medicine (CAM) use is highly prevalent in patients with epilepsy. Despite CAM’s widespread and increasing popularity, its prevalence, forms, perceived benefits, and potential risks in pediatric epilepsy are rarely explored. (2) Methods: We performed a scoping review of the available literature on the use of CAM in pediatric epilepsy. (3) Results: Overall, global cross-sectional studies showed a variable degree of CAM usage among children with epilepsy, ranging from 13 to 44% in prevalence. Popular types of CAMs reported were supplements, cannabis products, aromatherapy, herbal remedies, dietary therapy, massage therapy, and prayer. Families often report that CAM is effective, although there are limited objective measures of this. Potential risks lie in the use of CAM, such as herbal remedies, and/or unregulated, contaminated, or unpurified products. Studies also underscored inadequate patient–physician discussions regarding CAM. (4) Conclusions: A better understanding of this topic would aid clinicians in guiding patients/families on the use of CAM. Further studies on the efficacy of the different types of CAM used, as well as potential side effects and drug interactions are needed.

Publisher

MDPI AG

Subject

Pediatrics, Perinatology and Child Health

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