The Evolution of Scientific Knowledge in Childhood Asthma over Time: A Surprising History

Author:

Venditto Laura1ORCID,Morano Sonia1,Ferrante Giuliana1ORCID,Piazza Michele1ORCID,Tenero Laura1,Piacentini Giorgio1,Pecoraro Luca1ORCID

Affiliation:

1. Pediatric Clinic, Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37126 Verona, Italy

Abstract

Asthma is a disease that has been described since the times of Hammurabi. However, it is only since the 1960s that effective therapeutic strategies have been available. Pathogenic mechanisms underlying the disease have been deeply studied, contributing to creating a “patient-specific asthma” definition. Biological drugs have been approved over the last twenty years, improving disease management in patients with severe asthma via a “precision medicine-driven approach”. This article aims to describe the evolution of scientific knowledge in childhood asthma, focusing on the most recent biological therapies and their indications for patients with severe asthma.

Publisher

MDPI AG

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