POLB Regulates Proliferation and Apoptosis of Bovine Primary Myocytes-Reference-Cited by-同舟云学术

POLB Regulates Proliferation and Apoptosis of Bovine Primary Myocytes

Published:2024-04-28 Issue:9 Volume:14 Page:1323
ISSN:2076-2615
Container-title:Animals
language:en
Short-container-title:Animals

Author:

Zhang Geyang¹²,Wang Jiamei³,Li Yulong¹,Zhang Zijing¹,Wang Xiangnan¹,Chen Fuying¹,Shi Qiaoting¹,Huang Yongzhen³^ORCID,Wang Eryao¹,Lyu Shijie¹⁴

Affiliation:

1. Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China

2. College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China

3. College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

4. The Shennong Laboratory, Zhengzhou 450002, China

Abstract

DNA polymerase β (DNA polymerase beta (POLB)) belongs to a member of the DNA polymerase X family, mainly involved in various biological metabolic processes, such as eukaryotic DNA replication, DNA damage repair, gene recombination, and cell cycle regulation. In this study, the muscle development-related gene POLB was screened by selection signature and RNA-seq analysis and then validated for the proliferation and apoptosis of bovine primary myocytes. It was also found that overexpression of the POLB gene had a pro-apoptosis effect, but interfering with the expression of the gene had no significant effect on cells. Then, the analysis of related apoptotic genes revealed that POLB overexpression affected CASP9 gene expression.

Funder

The Key Scientific and Technological Special Projects of Henan Province

Publisher

MDPI AG

Link

https://www.mdpi.com/2076-2615/14/9/1323/pdf

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