The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease-Reference-Cited by-同舟云学术

The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease

Published:2023-09-26 Issue:10 Volume:13 Page:1446
ISSN:2218-273X
Container-title:Biomolecules
language:en
Short-container-title:Biomolecules

Author:

Trojan Václav¹,Landa Leoš¹²,Šulcová Alexandra¹,Slíva Jiří³^ORCID,Hřib Radovan¹⁴

Affiliation:

1. International Clinical Research Centre, Cannabis Facility, St. Anne’s University Hospital, Pekařská 53, 602 00 Brno, Czech Republic

2. Department of Pharmacology, Faculty of Medicine, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic

3. Department of Pharmacology, Third Faculty of Medicine, Charles University, Ruská 87, 100 00 Prague, Czech Republic

4. Centre for Pain Management, Department of Anesthesiology and Intensive Care, St. Anne’s University Hospital, Pekařská 53, 602 00 Brno, Czech Republic

Abstract

The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years. Presently, attention is paid to two main cannabinoids: delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). With respect to the psychotropic effects and dependence potential of THC (though it is very mild), its use is associated with certain restrictions, and thus the therapeutic properties of CBD are frequently emphasized because there are no limitations associated with the risk of dependence. Therefore, this review covers the main pharmacodynamic and pharmacokinetic features of CBD (including characteristics of endocannabinoidome) with respect to its possible beneficial effects on selected diseases in clinical practice. A substantial part of the text deals with the main effects of CBD on aging, including Alzheimer’s disease and related underlying mechanisms.

Funder

European Regional Development Fund—Project ENOCH

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry

Link

https://www.mdpi.com/2218-273X/13/10/1446/pdf

Reference109 articles.

1. Understanding the Odd Science of Aging;Kirkwood;Cell,2005

2. Di Marzo, V., and Wang, J. (2014). The Endocannabinoidome: The World of Endocannabinoids and Related Mediators, Academic Press. [1st ed.].

3. The molecular logic of endocannabinoid signalling;Piomelli;Nat. Rev. Neurosci.,2003

4. The Endocannabinoid System and its Modulation by Phytocannabinoids;Piscitelli;Neurotherapeutics,2015

5. Pharmacological actions of cannabinoids;Pertwee;Handbook of Experimental Pharmacology,2005