Vertical Transmission of SARS-CoV-2 in Second Trimester Associated with Severe Neonatal Pathology

Author:

Sukhikh Gennady,Petrova Ulyana,Prikhodko Andrey,Starodubtseva Natalia,Chingin KonstantinORCID,Chen Huanwen,Bugrova Anna,Kononikhin Alexey,Bourmenskaya Olga,Brzhozovskiy Alexander,Polushkina EvgeniyaORCID,Kulikova Galina,Shchegolev AlexanderORCID,Trofimov Dmitry,Frankevich Vladimir,Nikolaev Evgeny,Shmakov Roman G.

Abstract

The effects of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in women on the gestation course and the health of the fetus, particularly in the first and second trimesters, remain very poorly explored. This report describes a case in which the normal development of pregnancy was complicated immediately after the patient had experienced Coronavirus disease 2019 (COVID-19) at the 21st week of gestation. Specific conditions included critical blood flow in the fetal umbilical artery, fetal growth restriction (1st percentile), right ventricular hypertrophy, hydropericardium, echo-characteristics of hypoxic-ischemic brain injury (leukomalacia in periventricular area) and intraventricular hemorrhage at the 25th week of gestation. Premature male neonate delivered at the 26th week of gestation died after 1 day 18 h due to asystole. The results of independent polymerase chain reaction (PCR), mass spectrometry and immunohistochemistry analyses of placenta tissue, umbilical cord blood and child blood jointly indicated vertical transmission of SARS–CoV-2 from mother to the fetus, which we conclude to be the major cause for the development of maternal vascular malperfusion in the studied case.

Funder

Russian Foundation for Basic Research

Publisher

MDPI AG

Subject

Virology,Infectious Diseases

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