The Recent Management of Vestibular Schwannoma Radiotherapy: A Narrative Review of the Literature

Author:

Brun Lucie1,Mom Thierry2ORCID,Guillemin Florent3ORCID,Puechmaille Mathilde2,Khalil Toufic4,Biau Julian35

Affiliation:

1. Department of Radiation Oncology, University Hospital of Lyon, 69002 Lyon, France

2. Department of Otolaryngology-Head and Neck Surgery, University Hospital of Clermont-Ferrand, 63000 Clermont-Ferrand, France

3. Department of Radiation Oncology, Jean Perrin Center, 51 rue Montalembert, 63100 Clermont-Ferrand, France

4. Department of Neurological Surgery, University Hospital of Clermont-Ferrand, 63000 Clermont-Ferrand, France

5. INSERM U1240 IMoST, University of Clermont Auvergne, 63000 Clermont-Ferrand, France

Abstract

Background: Radiotherapy (RT) plays an important role in the therapeutic management of vestibular schwannoma (VS). Fractionated stereotactic radiotherapy (FSRT) or radiosurgery (SRS) are the two modalities available. The purpose of this article is to review the results of VS RT studies carried out over the last ten years. Materials and Methods: A literature search was performed with PubMed and Medline by using the words vestibular schwannoma, acoustic neuroma, radiotherapy, and radiosurgery. Results: In small (<3 cm) VS, SRS offers a local control rate of >90%, which seems similar to microsurgery, with a favorable tolerance profile. Hypofractionated FSRT (three to five fractions) is a relatively recent modality and has shown similar outcomes to normofractionated FSRT. Hearing preservation may highly differ between studies, but it is around 65% at 5 years. Conclusions: SRS and FRST are non-invasive treatment options for VS. SRS is often preferred for small lesions less than 3 cm, and FSRT for larger lesions. However, no randomized study has compared these modalities.

Publisher

MDPI AG

Reference70 articles.

1. Epidemiology, pathogenesis, and genetics of acoustic tumors;Lanser;Otolaryngol. Clin. N. Am.,1992

2. Incidence of Vestibular Schwannoma over the Past Half-Century: A Population-Based Study of Olmsted County, Minnesota;Marinelli;Otolaryngol. Head Neck Surg. Off. J. Am. Acad. Otolaryngol. Head Neck Surg.,2018

3. Vestibular schwannoma: 825 cases from a 25-year experience;Bento;Int. Arch. Otorhinolaryngol.,2012

4. Acoustic tumor observation and failure to follow-up;Hillman;Otolaryngol.-Head Neck Surg. Off. J. Am. Acad. Otolaryngol.-Head Neck Surg.,2010

5. Long-term hearing outcomes following stereotactic radiosurgery for vestibular schwannoma: Patterns of hearing loss and variables influencing audiometric decline;Carlson;J. Neurosurg.,2013

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