A Case of Ertapenem Neurotoxicity Resulting in Vocal Tremor and Altered Mentation in a Dialysis Dependent Liver Transplant Patient

Author:

Hanna Ramy,Sun Shih-Fan,Gaynor Pryce

Abstract

Carbapenem agents are advanced derivatives of cephalosporins that are active against bacteria that produce extended spectrum beta lactamases (ESBL). These antibiotics are resistant to enzymatic cleavage, and have good central nervous system penetration. Given this fact, it is not surprising that these drugs have been reported to cause neurological side effects like seizures and encephalopathy. We report a case of a patient on hemodialytic support who had a notable change in mentation and vocal tremor. This was at first attributed to calcineurin toxicity, but after the finding of a normal tacrolimus level, ertapenem neurotoxicity was suspected. After discontinuation of the offending agent, the patient’s vocal tremor, cognition, and neurological function returned to baseline levels.

Publisher

MDPI AG

Subject

Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology

Cited by 13 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Drug-Induced Tremors;Contemporary Clinical Neuroscience;2023

2. Safety profile of carbapenems: Data mining of the FDA adverse events reporting system;Int. Journal of Clinical Pharmacology and Therapeutics;2021-09-01

3. Serious Neurological Adverse Events of Ceftriaxone;Antibiotics;2021-05-06

4. Medicinal Chemistry of β‐Lactam Antibiotics;Burger's Medicinal Chemistry and Drug Discovery;2021-04-26

5. Ertapenem neurotoxicity in liver transplantation;Revista Española de Enfermedades Digestivas;2021

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