Effects of a Primary Care Antimicrobial Stewardship Program on Meticillin-Resistant Staphylococcus aureus Strains across a Region of Catalunya (Spain) over 5 Years-Reference-Cited by-同舟云学术

Effects of a Primary Care Antimicrobial Stewardship Program on Meticillin-Resistant Staphylococcus aureus Strains across a Region of Catalunya (Spain) over 5 Years

Published:2024-01-18 Issue:1 Volume:13 Page:92
ISSN:2079-6382
Container-title:Antibiotics
language:en
Short-container-title:Antibiotics

Author:

Jover-Sáenz Alfredo¹^ORCID,Ramírez-Hidalgo María¹,Bellés Bellés Alba²^ORCID,Ribes Murillo Esther³,Batlle Bosch Meritxell⁴,Ribé Miró Anna⁴,Mari López Alba⁵,Cayado Cabanillas José⁵^ORCID,Piqué Palacín Neus⁵,Garrido-Calvo Sònia⁶,Ortiz Valls Mireia⁶,Gracia Vilas María Isabel⁷,Gros Navés Laura⁸,Javierre Caudevilla María Jesús⁹,Montull Navarro Lidia¹⁰,Bañeres Argiles Cecilia¹⁰,Vaqué Castilla Pilar¹¹,Ichart Tomás José Javier¹²,Saura Codina Mireia¹²,Andreu Mayor Ester¹³,Martorell Solé Roser¹⁴,Vena Martínez Ana¹⁵,Albalad Samper José Manuel¹⁶,Cano Marrón Susana¹⁷,Soler Elcacho Cristina¹⁷,Rodríguez Garrocho Andrés¹⁷^ORCID,Terrer Manrique Gemma¹⁷,Solé Curcó Antoni¹⁸,Escuin David de la Rica¹⁹,Estadella Servalls María José²⁰,Figueres Farreny Ana M.²¹,Montaña Esteban Luís Miguel²²,Sanz Borrell Lidia²²,Morales Valle Arancha²³,Pallerola Planes Mercè²⁴,Hamadi Aly²⁴,Pujol Aymerich Francesc²⁵,Toribio Redondo Francisca²⁶,Urgelés Castillón María Cruz²⁷,Valgañon Palacios Juan²⁸,Olivart Parejo Marc²⁹,Torres-Puig-gros Joan³⁰, ,

Affiliation:

1. Unidad Territorial Infección Nosocomial (UTIN), Hospital Universitari Arnau de Vilanova de Lleida (HUAV), 25198 Lleida, Spain

2. Sección de Microbiología, Hospital Universitari Arnau de Vilanova de Lleida (HUAV), 25198 Lleida, Spain

3. Unidad de Farmacia de Atención Primaria, Institut Català de la Salut (ICS), 25007 Lleida, Spain

4. Equipo de Atención Priamaria (EAP) Les Borges Blanques, 25400 Lleida, Spain

5. EAP Pla d’Urgell, 25001 Lleida, Spain

6. EAP Balàfia-Pardinyes, 25005 Lleida, Spain

7. EAP Rambla de Ferran, 25007 Lleida, Spain

8. EAP Lleida Rural Nord, 25110 Lleida, Spain

9. Centre Penitenciari de Ponent, 25199 Lleida, Spain

10. EAP Eixample, 25006 Lleida, Spain

11. EAP Primer de Maig, 25002 Lleida, Spain

12. Servicio de Urgencias, Hospital Universitari Arnau de Vilanova de Lleida (HUAV), 25198 Lleida, Spain

13. Col·legi Oficial de Podòlegs, 25001 Lleida, Spain

14. EAP Cervera, 25200 Lleida, Spain

15. Servei de Geriatria, Hospital Universitari Santa Maria, 25198 Lleida, Spain

16. EAP Ponts, 25740 Lleida, Spain

17. EAP Onze de Setembre, 25005 Lleida, Spain

18. EAP Bellpuig, 25250 Lleida, Spain

19. EAP Artesa de Segre, 25730 Lleida, Spain

20. EAP Cappont, 25001 Lleida, Spain

21. EAP Almacelles, 25100 Lleida, Spain

22. EAP Seròs, 25183 Lleida, Spain

23. EAP Lleida Rural Sud, 25171 Lleida, Spain

24. EAP Balaguer, 25600 Lleida, Spain

25. EAP Alcarràs, 25180 Lleida, Spain

26. EAP Alfarràs-Almenar, 25120 Lleida, Spain

27. EAP Bordeta-Magraners, 25001 Lleida, Spain

28. EAP La Granadella, 25177 Lleida, Spain

29. EAP Tàrrega, 25300 Lleida, Spain

30. Departament de Salut Pública, Universitat de Lleida (UdL), 25006 Lleida, Spain

Abstract

Primary care antimicrobial stewardship program (ASP) interventions can reduce the over-prescription of unnecessary antibiotics, but the impact on the reduction in bacterial resistance is less known, and there is a lack of available data. We implemented a prolonged educational counseling ASP in a large regional outpatient setting to assess its feasibility and effectiveness. Over a 5-year post-implementation period, which was compared to a pre-intervention period, a significant reduction in antibiotic prescriptions occurred, particularly those associated with greater harmful effects and resistance selection. There was also a decrease in methicillin-resistant Staphylococcus aureus (MRSA) strains and in their co-resistance to other antibiotics, particularly those with an ecological impact.

Publisher

MDPI AG

Link

https://www.mdpi.com/2079-6382/13/1/92/pdf

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