Abstract
This study was performed to verify the clinical effect of a mouthwash containing Sambucus williamsii var. coreana extract on the acid production of oral bacteria and bacteria involved in dental caries. A randomized, double-blind, and placebo-controlled trial was conducted on 66 patients of the following groups: a Sambucus williamsii var. coreana extract gargle group (n = 34) and a saline solution gargle group (n = 32). According to the application time of a mouthwash (before gargle application, immediately after gargle application, and five days after gargle application), we examined the emergence of dental caries-causing bacteria by PCR analysis and changes in the amount of acid production in dental plaque through a Cariview test. As a result of verifying the effect of inhibiting and preventing dental caries in the oral environment, the dental caries-causing bacteria decreased in the Sambucus williamsii var. coreana extract gargle group compared to the saline gargle group. In particular, Streptococcus mutans showed a marked decrease from immediately after application of gargle to 5 days after application. In addition, the mouthwash containing Sambucus williamsii var. coreana extract did not cause acid production and had low dental caries activity. A mouthwash containing Sambucus williamsii var. coreana extract, a natural substance, can be used as an anti-dental caries agent and be commercialized as an effective dental caries prevention agent that is safe for teeth and has an excellent antibacterial effect.
Funder
National Research Foundation of Korea
Subject
Pharmacology (medical),Infectious Diseases,Microbiology (medical),General Pharmacology, Toxicology and Pharmaceutics,Biochemistry,Microbiology
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