1. Centre for Trials Research, Cardiff University, Cardiff CF14 4YS, UK
2. Division of Population Medicine, Cardiff University, Cardiff CF14 4YS, UK
3. Specialist Antimicrobial Chemotherapy Unit, University Hospital of Wales, Public Health Wales, Cardiff CF14 4XW, UK
4. PRIME Centre Wales, Division of Population Medicine, Cardiff University, Cardiff CF14 4YS, UK
5. Pragmatic Clinical Trials Unit, Queen Mary University of London, London E1 2AB, UK
6. Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK
7. Critical Care Directorate, Grange University Hospital, Aneurin Bevan University Health Board, Cwmbran NP44 8YN, UK
8. Department of Anaesthesia, Intensive Care and Pain Medicine, Cardiff University, Cardiff CF14 4XN, UK