Antifungal Activity of Aniba canelilla (Kunth) Mez Essential Oil and Its Main Compound 1-Nitro-2-Phenylethane against Dermatophytes-Reference-Cited by-同舟云学术

Antifungal Activity of Aniba canelilla (Kunth) Mez Essential Oil and Its Main Compound 1-Nitro-2-Phenylethane against Dermatophytes

Published:2024-05-24 Issue:6 Volume:13 Page:488
ISSN:2079-6382
Container-title:Antibiotics
language:en
Short-container-title:Antibiotics

Author:

Kreutz Tainá¹^ORCID,Duarte Eliane Oliveira Salines²^ORCID,Quatrin Priscilla Maciel³^ORCID,Carneiro Simone Braga⁴,Veiga-Junior Valdir F.⁴⁵^ORCID,Fuentefria Alexandre Meneghello¹³^ORCID,Koester Letícia S.¹

Affiliation:

1. Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil

2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil

3. Programa de Pós-Graduação em Microbiologia Agrícola e do Ambiente, Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, Santana, 2752, Porto Alegre 90610-000, Rio Grande do Sul, Brazil

4. Departamento de Química, Instituto de Ciências Exatas, Universidade Federal do Amazonas, Av. Gal. Rodrigo Octávio, Japiim, 6200, Manaus 69079-000, Amazonas, Brazil

5. Programa de Pós-Graduação em Química, Instituto Militar de Engenharia, Praça General Tibúrcio, Urca, 80, Rio de Janeiro 22290-270, Rio de Janeiro, Brazil

Abstract

The essential oil of Aniba canelilla (Kunth) Mez (EOAC), an Amazon plant composed of a rare nitro compound, has shown scientific evidence of antifungal activity but is still unexplored against dermatophytes. The antifungal susceptibility of EOAC and its main compound, 1-nitro-2-phenylethane (NP), was evaluated against dermatophytes (Trichophyton rubrum, T. mentagrophytes and Microsporum canis), evidencing antifungal activity with an inhibitory concentration lower than 256 μg/mL. The mechanism of action was also evaluated, and it is suggested that EOAC and NP have fungicidal action in the fungal membrane, since the antifungal activity occurs through a modification of the shape of the conidial structures of the fungus, showing the permeability of the intracellular content due to the visually observed plasmolysis and cytosolic extravasation through an osmotic process. These results suggest the essential oil and its main compound are promising plant-derived alternatives for treating ungual dermatophytosis.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior/Ministério da Educação—CAPES/MEC

Conselho Nacional de Desenvolvimento Científico e Tecnológico—CNPq

Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro—FAPERJ

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul—FAPERGS

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil—CAPES

Publisher

MDPI AG

Link

https://www.mdpi.com/2079-6382/13/6/488/pdf

Reference30 articles.

1. Onychomycosis: Current and Investigational Therapies;Lipner;Cutis,2014

2. Maskan Bermudez, N., Rodríguez-Tamez, G., Perez, S., and Tosti, A. (2023). Onychomycosis: Old and New. J. Fungi, 9.

3. A Large-Scale North American Study of Fungal Isolates from Nails: The Frequency of Onychomycosis, Fungal Distribution, and Antifungal Susceptibility Patterns;Ghannoum;J. Am. Acad. Dermatol.,2000

4. Global Prevalence of Onychomycosis in General and Special Populations: An Updated Perspective;Gupta;Mycoses,2024

5. Onychomycosis: Evaluation, Treatment Options, Managing Recurrence, and Patient Outcomes;Vlahovic;Clin. Podiatr. Med. Surg.,2016