Structural and Functional Retinal Changes in Patients with Mild Cognitive Impairment with and without Diabetes-Reference-Cited by-同舟云学术

Structural and Functional Retinal Changes in Patients with Mild Cognitive Impairment with and without Diabetes

Published:2023-11-10 Issue:22 Volume:12 Page:7035
ISSN:2077-0383
Container-title:Journal of Clinical Medicine
language:en
Short-container-title:JCM

Author:

Santos-Ortega Álvaro¹,Alba-Linero Carmen²³,Urbinati Facundo⁴,Rocha-de-Lossada Carlos⁴⁵⁶⁷^ORCID,Orti Rafael³,Reyes-Bueno José Antonio⁸,Garzón-Maldonado Francisco Javier⁹¹⁰^ORCID,Serrano Vicente⁹,de Rojas-Leal Carmen⁹¹⁰,de la Cruz-Cosme Carlos⁹¹⁰,España-Contreras Manuela⁴,Rodríguez-Calvo-de-Mora Marina⁴⁵⁶,García-Casares Natalia¹⁰¹¹¹²^ORCID

Affiliation:

1. Department of Ophthalmology, Hospital Costa del Sol, 29603 Malaga, Spain

2. Department of Ophthalmology, Hospital Universitario Virgen de la Victoria, 29010 Malaga, Spain

3. Department of Ophthalmology, Faculty of Medicine, University of Malaga, 29016 Malaga, Spain

4. Department of Ophthalmology, Hospital Regional Universitario, 29011 Malaga, Spain

5. Qvision, Opththalmology Department, VITHAS Almería Hospital, 04120 Almería, Spain

6. Ophthalmology Department, VITHAS Málaga, 29016 Malaga, Spain

7. Department of Surgery, Faculty of Medicine, Ophthalmology Area Doctor Fedriani, University of Sevilla, 41004 Sevilla, Spain

8. Department of Neurology, Hospital Regional Universitario, 29011 Malaga, Spain

9. Department of Neurology, Hospital Virgen de la Victoria, 29010 Malaga, Spain

10. Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Malaga, Spain

11. Department of Medicine, Faculty of Medicine, University of Malaga, 29016 Malaga, Spain

12. Centro de Investigaciones Médico-Sanitarias (CIMES), University of Malaga, 29016 Malaga, Spain

Abstract

Our objective is to analyze retinal changes using optical coherence tomography angiography (OCT-A) in patients with mild cognitive impairment (MCI) to characterize structural and vascular alterations. This cross-sectional study involved 117 eyes: 39 eyes from patients with MCI plus diabetes (DM-MCI), 39 eyes from patients with MCI but no diabetes (MCI); and 39 healthy control eyes (C). All patients underwent a visual acuity measurement, a structural OCT, an OCT-A, and a neuropsychological examination. Our study showed a thinning of retinal nerve fiber layer thickness (RNFL) and a decrease in macular thickness when comparing the MCI-DM group to the C group (p = 0.008 and p = 0.016, respectively). In addition, an increase in arteriolar thickness (p = 0.016), a reduction in superficial capillary plexus density (p = 0.002), and a decrease in ganglion cell thickness (p = 0.027) were found when comparing the MCI-DM group with the MCI group. Diabetes may exacerbate retinal vascular changes when combined with mild cognitive impairment.

Publisher

MDPI AG

Subject

General Medicine

Link

https://www.mdpi.com/2077-0383/12/22/7035/pdf

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