The Therapy of Vulvar Carcinoma—Evaluation of Surgical Options in a Retrospective Monocentric Study

Author:

Jankowski Peter1,Findeklee Sebastian1ORCID,Georgescu Mihai-Teodor23ORCID,Sima Romina Marina45,Nigdelis Meletios P.16ORCID,Solomayer Erich-Franz1,Klamminger Gilbert Georg1ORCID,Hamoud Bashar Haj1

Affiliation:

1. Department for Gynecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, 66421 Homburg, Germany

2. Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, Romania

3. “Prof. Dr. Alexandru Trestioreanu” Oncology Institute, 022328 Bucharest, Romania

4. Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania

5. The “Bucur” Maternity, ‘Saint John’ Hospital, 040294 Bucharest, Romania

6. Unit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Papageorgiou General Hospital, Aristotle University of Thessaloniki, 56403 Thessaloniki, Greece

Abstract

(1) Background: Surgical-oncological treatment methods are continuously put to the test in times of evidence-based medicine—notably, a constant reevaluation remains key, especially for tumor entities with increasing incidence such as vulvar carcinoma. (2) Methods: In order to determine the postoperative clinical course of different methods of vulvar excision (vulvectomy, hemivulvectomy) as well as inguinal lymph node removal (lymphadenectomy, sentinel lymph node biopsy) with regard to postoperative wound-healingprocess, perioperative hemorrhage, and re-resection rates, we retrospectively analyzed surgical, morphological and laboratory data of 76 patients with a pathological diagnosed vulvar cancer. (3) Results: Analysis of our data from a single center revealed a comparable perioperative clinical course regardless of the chosen method of vulvar excision and inguinal lymph node removal. (4) Conclusions: Thus, our results emphasize the current multimodality in surgical therapy of vulvar carcinoma, in which consideration of known prognostic factors together with the individual patient’s clinical situation allow guideline-based therapy aimed at maximizing surgical safety.

Publisher

MDPI AG

Subject

Paleontology,Space and Planetary Science,General Biochemistry, Genetics and Molecular Biology,Ecology, Evolution, Behavior and Systematics

Reference32 articles.

1. A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women;Joura;N. Engl. J. Med.,2014

2. HPV-related cancers after solid organ transplantation in the United States;Madeleine;Am. J. Transpl.,2016

3. US assessment of HPV types in cancers: Implications for current and 9-valent HPV vaccines;Saraiya;J. Natl. Cancer Inst.,2020

4. Preoperative radiation therapy for locally advanced vulvar cancer;Hacker;Cancer,1984

5. Karlan, B.Y., Bristow, R.E., and Li, A.J. (2015). Gynecologic Oncology: Clinical Practice and Surgical Atlas, McGraw Hill. Available online: https://obgyn.mhmedical.com/content.aspx?bookid=1381§ionid=75542055.

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