Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis-Reference-Cited by-同舟云学术

Exploring the Conformational Equilibrium of Mefenamic Acid Released from Silica Aerogels via NMR Analysis

Published:2023-04-07 Issue:8 Volume:24 Page:6882
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Khodov Ilya¹^ORCID,Sobornova Valentina¹^ORCID,Mulloyarova Valeriya²,Belov Konstantin¹^ORCID,Dyshin Alexey¹^ORCID,de Carvalho Luís Batista³^ORCID,Tolstoy Peter²^ORCID,Kiselev Michael¹

Affiliation:

1. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo 153045, Russia

2. Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 198504, Russia

3. Molecular Physical-Chemistry R&D Unit, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal

Abstract

This study examines the influence of mefenamic acid on the physical and chemical properties of silica aerogels, as well as its effect on the sorption characteristics of the composite material. Solid state magic angle spinning nuclear magnetic resonance (MAS NMR) and high-pressure 13C NMR kinetic studies were conducted to identify the presence of mefenamic acid and measure the kinetic rates of CO2 sorption. Additionally, a high-pressure T1–T2 relaxation-relaxation correlation spectroscopy (RRCOSY) study was conducted to estimate the relative amount of mefenamic acid in the aerogel’s pores, and a high-pressure nuclear Overhauser effect spectoscopy (NOESY) study was conducted to investigate the conformational preference of mefenamic acid released from the aerogel. The results indicate that mefenamic acid is affected by the chemical environment of the aerogel, altering the ratio of mefenamic acid conformers from 75% to 25% in its absence to 22% to 78% in the presence of aerogel.

Funder

Russian Science Foundation

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/8/6882/pdf

Reference96 articles.

1. An Enzyme-Responsive Controlled Release System of Mesoporous Silica Coated with Konjac Oligosaccharide;Guo;Langmuir,2014

2. Drug Loading of Polymer Implants by Supercritical CO2 Assisted Impregnation: A Review;Champeau;J. Control. Release,2015

3. Feasibility Study of Hydrophilic and Hydrophobic Silica Aerogels as Drug Delivery Systems;Smirnova;J. Non. Cryst. Solids,2004

4. Enhanced Dissolution Rate and Synchronized Release of Drugs in Binary Systems through Formulation: Amorphous Naproxen–cimetidine Mixtures Prepared by Mechanical Activation;Alleso;J. Control. Release,2009

5. Stabilized Amorphous State of Ibuprofen by Co-Spray Drying With Mesoporous SBA-15 to Enhance Dissolution Properties;Shen;J. Pharm. Sci.,2010

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