Antiviral Activity of Quercetin Hydrate against Zika Virus

Author:

Saivish Marielena Vogel12ORCID,Menezes Gabriela de Lima34ORCID,da Silva Roosevelt Alves4ORCID,Fontoura Marina Alves2ORCID,Shimizu Jacqueline Farinha2,da Silva Gislaine Celestino Dutra1,Teixeira Igor da Silva1ORCID,Mistrão Natalia Franco Bueno1,Hernandes Victor Miranda1,Rahal Paula5,Sacchetto Lívia1ORCID,Pacca Carolina Colombelli156,Marques Rafael Elias2ORCID,Nogueira Maurício Lacerda127ORCID

Affiliation:

1. Laboratório de Pesquisas em Virologia, Departamento de Doenças Dermatológicas, Infecciosas e Parasitárias, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto 15090-000, SP, Brazil

2. Brazilian Biosciences National Laboratory, Centro Nacional de Pesquisa em Energia e Materiais (CNPEM), Campinas 13083-100, SP, Brazil

3. Departamento de Biofísica e Farmacologia, Universidade Federal do Rio Grande do Norte, Natal 59072-970, RN, Brazil

4. Unidade Especial de Ciências Exatas, Universidade Federal de Jataí, Jataí 75801-615, GO, Brazil

5. Laboratório de Estudos Genômicos, Departamento de Biologia, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista, São José do Rio Preto 15054-000, SP, Brazil

6. Departamento de Microbiologia, Faceres Medical School, São José do Rio Preto 15090-000, SP, Brazil

7. Department of Pathology, The University of Texas Medical Branch, Galveston, TX 77555-0609, USA

Abstract

Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic re-emergence and clinical impact, no vaccines or antiviral compounds are available to prevent or control ZIKV infection. This study evaluated the potential antiviral activity of quercetin hydrate against ZIKV infection and demonstrated that this substance inhibits virus particle production in A549 and Vero cells under different treatment conditions. In vitro antiviral activity was long-lasting (still observed 72 h post-infection), suggesting that quercetin hydrate affects multiple rounds of ZIKV replication. Molecular docking indicates that quercetin hydrate can efficiently interact with the specific allosteric binding site cavity of the NS2B-NS3 proteases and NS1-dimer. These results identify quercetin as a potential compound to combat ZIKV infection in vitro.

Funder

São Paulo Research Foundation

National Institutes of Health

FAPESP PhD Scholarship

CAPES PhD Scholarship

CNPq PhD Scholarship

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Reference77 articles.

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2. Zika: The Origin and Spread of a Mosquito-Borne Virus;Kindhauser;Bull. World Health Organ.,2016

3. (2022, November 01). The History of Zika Virus. Available online: https://www.who.int/news-room/feature-stories/detail/the-history-of-zika-virus.

4. Zika Virus Outbreak on Yap Island, Federated States of Micronesia;Duffy;N. Engl. J. Med.,2009

5. Zika Virus-Spread, Epidemiology, Genome, Transmission Cycle, Clinical Manifestation, Associated Challenges, Vaccine and Antiviral Drug Development;Pielnaa;Virology,2020

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