Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans-Reference-Cited by-同舟云学术

Sweat Testing for the Detection of Methylone after Controlled Administrations in Humans

Published:2023-04-17 Issue:8 Volume:24 Page:7395
ISSN:1422-0067
Container-title:International Journal of Molecular Sciences
language:en
Short-container-title:IJMS

Author:

Di Giorgi Alessandro¹,Sprega Giorgia¹,Poyatos Lourdes²³^ORCID,Papaseit Esther²³,Pérez-Mañá Clara²³^ORCID,Di Trana Annagiulia⁴,Varì Maria Rosaria⁴^ORCID,Busardò Francesco Paolo¹,Pichini Simona⁴,Zaami Simona⁵^ORCID,Lo Faro Alfredo Fabrizio¹^ORCID,Farré Magí²³^ORCID

Affiliation:

1. Department of Excellence-Biomedical Sciences and Public Health, Università Politecnica delle Marche, 60121 Ancona, Italy

2. Department of Clinical Pharmacology, Hospital Universitari Germans Trias i Pujol and Institut de Recerca Germans Trias i Pujol (HUGTiP-IGTP), 08916 Badalona, Spain

3. Department of Pharmacology, Therapeutics and Toxicology and Department of Psychiatry and Forensic Medicine, Universitat Autònoma de Barcelona (UAB), 08193 Cerdanyola del Vallés, Spain

4. National Centre on Addiction and Doping, Istituto Superiore di Sanità, 00161 Rome, Italy

5. Department of Anatomical, Histological, Forensic, and Orthopedic Sciences, Università La Sapienza, 00161 Rome, Italy

Abstract

The aim of this study was to determine the excretion of methylone and its metabolites in sweat following the ingestion of increasing controlled doses of 50, 100, 150 and 200 mg of methylone to twelve healthy volunteers involved in a clinical trial. Methylone and its metabolites 4-hydroxy-3-methoxy-N-methylcathinone (HMMC) and 3,4-methylenedioxycathinone (MDC) were analyzed in sweat patches by liquid chromatography–tandem mass spectrometry. Methylone and MDC were detected in sweat at 2 h and reached their highest accumulation (Cmax) at 24 h after the administration of 50, 100, 150 and 200 mg doses. In contrast, HMMC was not detectable at any time interval after each dose. Sweat proved to be a suitable matrix for methylone and its metabolites’ determination in clinical and toxicological studies, providing a concentration that reveals recent drug consumption.

Publisher

MDPI AG

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Computer Science Applications,Spectroscopy,Molecular Biology,General Medicine,Catalysis

Link

https://www.mdpi.com/1422-0067/24/8/7395/pdf

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