Chitosan Effect on Hardening Dynamics of Calcium Phosphate Cement: Low-Field NMR Relaxometry Investigations

Abstract

Calcium phosphate cements are used in dentistry and orthopedics to repair and reconstruct bone defects. The properties of these bone cements can be improved by introducing additives into their composition. One favorable additive is chitosan, which can be beneficial but can also cause considerable damage if it has a high load, thus, limiting its clinical applicability and performance. That is why understanding chitosan’s role in cement composition is an important issue when developing new materials. The present work uses low-field nuclear magnetic resonance (NMR) relaxometry to investigate the effect introduced by the addition of chitosan on the hardening process of calcium phosphate cement. Two samples, prepared with and without chitosan, were comparatively investigated during the first six minutes of hardening. The liquid evolution inside these samples was monitored using transverse relaxation time distributions. It demonstrated an acceleration effect on the hardening dynamics introduced by the presence of chitosan. Furthermore, it was shown that even after one hour of hardening, there were still unreacted monomers inside the bone cement and their amount was reduced in the presence of chitosan.